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Related Experiment Video

Updated: Jun 21, 2026

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

Bioactive compounds: safety and efficacy.

Hans-Konrad Biesalski¹, Lars Ove Dragsted, Ibrahim Elmadfa

¹Department of Biological Chemistry and Nutrition, University of Hohenheim, Stuttgart, Germany. biesal@uni-hohenheim.de

Nutrition (Burbank, Los Angeles County, Calif.)

|August 12, 2009

Summary

Defining safe and effective doses for bioactive compounds is complex. Experts convened to address challenges in determining physiologic doses and safety parameters, considering individual variability.

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Last Updated: Jun 21, 2026

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

Area of Science:

Pharmacology
Nutritional Science
Toxicology

Background:

Bioactive compound efficacy and safety are influenced by numerous known and unknown factors.
Determining appropriate dosages for bioactive compounds with limited pharmacokinetic data presents significant challenges.

Framework:

The concept of a "physiologic dose" requires clear definition, especially for compounds with poorly understood supply and distribution.
Establishing necessary safety parameters is crucial for risk assessment.
Individual variations, including genetic polymorphisms and absorption differences, must be integrated into dose-setting methodologies.

Implementation:

The 23rd Hohenheim Consensus Meeting convened experts to discuss these critical issues.
The meeting focused on developing frameworks for defining and assessing bioactive compound doses and safety.

Implications:

This expert consensus aims to improve the scientific basis for evaluating bioactive compound safety and efficacy.
Addressing these knowledge gaps will enhance the responsible use of bioactive compounds in various applications.