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5-HT3 receptor antagonists attenuate dopamine-induced hyperactivity in the rat
B Costall1, A M Domeney, R J Naylor
1Postgraduate Studies in Pharmacology, School of Pharmacy, University of Bradford, West Yorkshire, U.K.
Neuroreport
|September 1, 1990
Abstract:
The 5-HT3 receptor antagonists, ICS205-930, granisetron and zacopride, at low doses, inhibited the hyperactivity caused by a 13 day mesolimbic dopamine infusion in the rat. The antagonism decreased with the use of higher doses of the 5-HT3 receptor antagonists. The ability of low doses of the 5-HT3 receptor antagonists to inhibit dopamine-induced behavioural changes is similar to the inhibitory profile of known antipsychotic agents. It is suggested that 5-HT3 receptor antagonists may represent a new class of atypical antipsychotic agents.