Related Experiment Video
Updated: Jun 21, 2026
08:32
Development and Assessment of Intracellular Infection Models for Staphylococcus aureus
Published on: January 17, 2025
Concomitant Staphylococcus aureus bacteriuria is associated with complicated S. aureus bacteremia
Céline Pulcini1, Matta Matta, Véronique Mondain
1Centre Hospitalier Universitaire de Nice, Service d'Infectiologie, Hôpital l'Archet 1, BP 3079, 06202 Nice Cedex 3, France. pulcini.c@chu-nice.fr
The Journal of Infection
|August 12, 2009
Summary
Community-acquired Staphylococcus aureus bacteremia (SAB), concurrent bacteriuria, and persistent bacteremia are linked to complicated SAB. Persistent bacteremia specifically correlates with endocarditis in adult patients.
Area of Science:
- Infectious Diseases
- Clinical Microbiology
- Epidemiology
Background:
- Staphylococcus aureus bacteremia (SAB) is a serious infection.
- Identifying factors associated with complicated SAB is crucial for patient management.
Purpose of the Study:
- To determine factors linked to complicated Staphylococcus aureus bacteremia in adult inpatients.
Main Methods:
- A prospective observational multicenter study was conducted.
- Inclusion criteria involved adult inpatients with SAB assessed by Infectious Diseases specialists.
Main Results:
- Out of 104 SAB cases, 45 were complicated, including endocarditis and bone/joint infections.
- Community acquisition, concomitant bacteriuria, and persistent bacteremia were associated with complicated SAB (P<0.05).
Conclusions:
- Community acquisition, bacteriuria, and persistent bacteremia are significant factors for complicated SAB.
- Persistent bacteremia is particularly associated with endocarditis in SAB cases.
Related Concept Videos
01:29Staphylococcal Skin Infections
Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
01:25Urinary Tract Infection II: Pathophysiology
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
01:26Urinary Tract Infection I: Introduction
Urinary tract infections (UTIs) impact various parts of the urinary system, including the kidneys, ureters, bladder, and urethra. These infections are generally bacterial, with Escherichia coli being the most common causative agent, often originating from the gastrointestinal tract. However, other bacteria, such as Staphylococcus saprophyticus, Klebsiella pneumoniae, and Proteus mirabilis, are also known to cause UTIs. The type, location, and underlying complexity of the UTI guide both...
01:25Mechanism of Antibiotic Resistance in MRSA
Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
01:25Clinical Significance of Antibiotic Resistance
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
01:26Urine Studies II: Urine Culture and Sensitivity Test
A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...