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Updated: Jun 21, 2026

Development and Assessment of Intracellular Infection Models for Staphylococcus aureus
Published on: January 17, 2025
Concomitant Staphylococcus aureus bacteriuria is associated with complicated S. aureus bacteremia
Céline Pulcini1, Matta Matta, Véronique Mondain
1Centre Hospitalier Universitaire de Nice, Service d'Infectiologie, Hôpital l'Archet 1, BP 3079, 06202 Nice Cedex 3, France. pulcini.c@chu-nice.fr
Objectives:
To identify factors associated with complicated Staphylococcus aureus bacteremia (SAB) in adults.
Methods:
Prospective observational multicenter study during 2 years in Nice University Hospital and during 6 months in the Hôpital Européen Georges Pompidou, Paris, including all adult inpatients with SAB assessed by an Infectious Diseases (ID) specialist.
Results:
We included 104 SAB (79 in Nice and 25 in Paris), of which 45 were complicated, including 18 endocarditis and 23 bone and joint infections. A concomitant urine sample was performed in 65% of the cases, showing S. aureus bacteriuria 23/68 (34%) times. Blood cultures were drawn 48-96h after an appropriate antibiotic therapy had been started in 70 of the 104 cases (67%) and were positive in 28 cases (40%).
Conclusions:
The 3 following factors were found to be associated with complicated SAB in univariate analysis: community acquisition (56% vs 26%, P=0.002), concomitant bacteriuria (47% vs 19%, P=0.016) and persistent bacteremia (55% vs 26%, P=0.016). This last factor was associated with endocarditis, but not with other complications such as bone and joint infections.
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