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Related Concept Videos

Malaria01:29

Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...
Phosphorylation01:02

Phosphorylation

The addition or removal of phosphate groups from proteins is the most common chemical modification that regulates cellular processes. These modifications can affect the structure, activity, stability, and localization of proteins within cells as well as their interactions with other proteins.
During phosphorylation, protein kinases transfer the terminal phosphate group of ATP to specific amino acid side chains of substrate proteins. Serine, threonine, and tyrosine are the most commonly...
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein.
Diversity of Protists II01:27

Diversity of Protists II

Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...
Symbiosis00:58

Symbiosis

Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
Protein Kinases and Phosphatases02:54

Protein Kinases and Phosphatases

Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation, acetylation, glycosylation, nitrosylation, ubiquitination, lipidation, methylation, and proteolysis are various protein modifications that regulate protein activity. Such modifications are usually enzyme-driven.
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...

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Related Experiment Video

Updated: Jun 21, 2026

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum
10:22

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Published on: December 4, 2015

Post-translational modifications in Plasmodium: more than you think!

Duk-Won Doug Chung1, Nadia Ponts, Serena Cervantes

  • 1Department of Cell Biology and Neuroscience, University of California, Riverside, 900 University Avenue, Riverside, CA 92521, USA.

Molecular and Biochemical Parasitology
|August 12, 2009
PubMed
Summary

Investigating post-translational modifications in Plasmodium offers new drug discovery avenues. This research explores these modifications to understand the parasite

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Published on: September 18, 2018

Area of Science:

  • Malariology
  • Parasitology
  • Molecular Biology

Background:

  • Plasmodium transcription appears rigid, unlike typical gene regulation.
  • Understanding alternative regulatory pathways is crucial for combating malaria.
  • Post-translational modifications (PTMs) represent an emerging research area in Plasmodium.

Purpose of the Study:

  • To review recent findings on PTMs in Plasmodium.
  • To highlight the potential of PTMs in malaria drug discovery.
  • To explore how PTMs regulate the Plasmodium life cycle.

Main Methods:

  • Literature review of recent studies on Plasmodium PTMs.
  • Analysis of current understanding of PTMs in parasitic protozoans.

Main Results:

  • PTMs are increasingly recognized as key regulatory mechanisms in Plasmodium.
  • Specific PTMs influence various aspects of the parasite's biology and life cycle.
  • This field offers novel targets for antimalarial drug development.

Conclusions:

  • PTMs are vital for Plasmodium survival and proliferation.
  • Targeting PTMs presents a promising strategy for new antimalarial therapies.
  • Further research into Plasmodium PTMs is essential for malaria control.