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Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
Published on: May 6, 2022
Association between interleukin-1 beta polymorphism (+3953) and obesity.
M F Manica-Cattani1, L Bittencourt, M I U Rocha
1Programa de Pós-Graduação em Ciências Biológicas (Bioquímica Toxicológica), Universidade Federal de Santa Maria, Brazil.
Molecular and Cellular Endocrinology
|August 12, 2009
Summary
The interleukin-1 beta (IL-1) gene polymorphism is linked to obesity. The CC genotype of the IL-1 beta +3953 (C>T) polymorphism was more frequent in obese Caucasians, suggesting a role in obesity development.
Area of Science:
- Immunology
- Genetics
- Obesity Research
Background:
- Obesity is linked to low-grade inflammation driven by innate immune system activation, specifically interleukin-1 beta (IL-1).
- Previous studies suggest a positive association between the IL-1 beta +3953 (C>T) gene polymorphism (rs 1143634) and obesity, impacting fat mass and metabolism.
Purpose of the Study:
- To investigate the association between the IL-1 beta +3953 C/T polymorphism and obesity in a Caucasian population.
- To determine if sex and age influence the relationship between this polymorphism and obesity.
Main Methods:
- A case-control study was conducted with 880 Caucasian subjects from the Brazilian Aging Research Program.
- Participants were categorized into non-overweight (n=283), overweight (n=334), and obese (n=263) groups.
- The IL-1 beta +3953 C/T polymorphism was analyzed using genetic studies.
Main Results:
- A higher frequency of the T allele (CT/TT genotypes) was observed in the non-overweight group compared to overweight and obese groups.
- The odds ratio indicated a 1.340 times greater chance of the obese group being CC genotype carriers versus the non-overweight group, independent of sex and age.
Conclusions:
- The findings support the link between the interleukin-1 beta system and obesity development.
- The IL-1 beta +3953 C/T polymorphism, specifically the CC genotype, may be a genetic factor contributing to obesity in this Caucasian population.
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