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Updated: Jun 21, 2026
Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
Published on: January 7, 2019
[MELD or Maddrey?: comparison of two prognosis models in patients with alcohol toxic hepatitis]
L Zapata-Irrisón1, J J Jurado-Nuñez, J T Altamirano-Gómez
1Servicio de Gastroenterología y Dirección de Enseñanza e Investigación, Hospital Juárez de México, México, Distrito Federal.
Background:
The toxic hepatitis is the most common manifestation of acute liver disease in patient with alcohol. In these patients the discriminatory function index (DFI) > 32, has been associated with a mortality rate of up to 50%. MELD is a scale that has been recently validated as independent risk factors for death in patients who are candidates for liver transplantation.
Objectives:
To compare the usefulness in mortality score vs. MELD. Maddrey index of discrimination in patients with alcoholic hepatitis and analyze the factors in a cohort Mexican prognosis.
Materials And Methods:
We evaluated the usefulness of MELD, compared with the index of discrimination Maddrey so retrospective in 67 hospitalized patients with alcoholic hepatitis in the Hospital Juárez in Mexico.
Results:
The c-statistic for mDFI was 0.69 (CI 0.56-0.82) and to MELD was 0.73 (CI 0.61-0.86), sensitivity and specificity of DFI > 32 in 7 days to predict mortality was 100 and 7.1% , Respectively, and to meld > 21 sensitivity was 96% and specificity of 9.5%. The presence of encephalopathy > grade 2 and creatinine > 1.5 mg/dL was independent predictors of mortality.
Conclusions:
MELD > 21 calculated on admission, is equally useful for the mDFI for predicting mortality in patients with alcoholic hepatitis in the first week.
