[Scavenging effects of sodium ferulate and 18 beta-glycyrrhetic acid on oxygen free radicals]

The scavenging effects of sodium ferulate (SF) and glycyrrhetic acid (GA) on oxygen free radicals were studied by using spin trapping technique and chemiluminescence (CL) methods. SF 0.3 mmol/L and GA 0.3 mmol/L effectively scavenged oxygen free radicals produced by phorbol myristate acetate (PMA)-stimulated polymorphonuclear leukocytes (PMN), but had no effect on the oxygen consumption by PMN, measured with spin probe oxymetry. In 3 cell-free oxygen free radical generating systems, both SF and GA showed a remarkably scavenging effects on O2- and OH.. SF 30 mumol/L and GA 30 mumol/L prominently inhibited the CL response of PMA-stimulated PMN. The results demonstrated that SF and GA are oxygen free radical scavengers.