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Published on: January 7, 2018
Prehypertension is associated with insulin resistance
1Section of Endocrinology and Metabolism, Taipei Veterans General Hospital, Taipei 112, Taiwan. chhwu@vghtpe.gov.tw
QJM : Monthly Journal of the Association of Physicians
|August 12, 2009
Summary
Prehypertension is linked to insulin resistance (IR), a key feature of metabolic abnormalities. Individuals with prehypertension show poorer glucose tolerance, suggesting IR contributes to elevated blood pressure.
Area of Science:
- Cardiovascular Health
- Metabolic Syndrome
- Hypertension Research
Background:
- Prehypertension, defined by JNC-7 guidelines, predicts future hypertension.
- Insulin resistance (IR) is implicated in hypertension's metabolic abnormalities and may precede elevated blood pressure.
Purpose of the Study:
- To investigate the association between prehypertension and insulin resistance.
Main Methods:
- Cross-sectional study involving 83 prehypertensive and 192 normotensive subjects.
- Measurements included anthropometrics, blood pressure, and a 75-g oral glucose tolerance test (OGTT) to assess IR.
Main Results:
- Prehypertensive subjects exhibited higher obesity, fasting triglycerides, and 2-hour insulin levels.
- Lower insulin sensitivity index (ISI(0,120)) values indicated greater IR in the prehypertension group.
- Despite no difference in insulin response after adjustments, prehypertensive individuals showed impaired glucose response.
Conclusions:
- Prehypertension is significantly associated with insulin resistance.
- Prehypertensive individuals display clinical characteristics consistent with the IR syndrome.
- Impaired oral glucose challenge handling in prehypertension likely results from underlying IR.
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