Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Protein Networks

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...

Protein Networks

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...

IP3/DAG Signaling Pathway

IP3/DAG Signaling Pathway

Membrane lipids such as phosphatidylinositol (PI) are precursors for several membrane-bound and soluble second messengers. Specific kinases phosphorylate PI and produce phosphorylated inositol phospholipids. One such inositol phospholipids are the phosphatidylinositol-4,5 bisphosphate [PI(4,5)P2], present in the inner half of the lipid bilayer. Upon ligand binding, GPCR stimulates Gq proteins to turn on phospholipase Cꞵ. Activated phospholipase Cꞵ cleaves PI(4,5)P2 and produces two-second...

Fibronectins Connect Cells with ECM

Fibronectins Connect Cells with ECM

Fibronectin is an adhesive glycoprotein present in the extracellular matrix of embryogenic and adult tissue. These molecules primarily aid in regulating cell motility and attachment. A fibronectin molecule is composed of two identical polypeptide chains attached to each other by a pair of disulfide bonds at the C-terminal.
Both proteoglycans and collagen are attached to fibronectin proteins, which, in turn, are attached to integrin proteins. These integrin proteins interact with transmembrane...

Applications of Molecular Taxonomy

Applications of Molecular Taxonomy

Molecular taxonomy has revolutionized the understanding and classification of bacteria, providing precise insights into their diversity, evolutionary relationships, and ecological roles. By utilizing molecular techniques such as DNA sequencing and fingerprinting, researchers have made significant strides in various fields related to bacterial studies.Resolving Taxonomic AmbiguitiesMolecular taxonomy has been instrumental in distinguishing closely related bacterial species initially thought to...

Cell-surface Signaling

Cell-surface Signaling

Hormones—or any molecule that binds to a receptor, known as a ligand—that are lipid-insoluble (water-soluble) are not able to diffuse across the cell membrane. In order to be able to affect a cell without entering it, these hormones bind to receptors on the cell membrane. When a first messenger, a hormone, binds to a receptor, a signal cascade is set off, causing second messengers, proteins inside the cell, to become activated, resulting in downstream effects.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Unfurling the role of dysferlin's C2A domain.

The Journal of general physiology·2026

Same author

Cholesterol pools cooperate to modulate HCN channels.

The Journal of general physiology·2026

Same author

ID helps verify coincidence detection.

The Journal of general physiology·2026

Same author

Cavβ dances the two-step with VSD II.

The Journal of general physiology·2025

Same author

The origins of oscillations.

The Journal of general physiology·2025

Same author

Skeletal muscle gets some help down the stretch.

The Journal of general physiology·2025

Search research articles

Related Experiment Video

Updated: Jun 21, 2026

BioMEMS: Forging New Collaborations Between Biologists and Engineers

BioMEMS: Forging New Collaborations Between Biologists and Engineers

Published on: November 1, 2007

Cell biologists expand their networks.

¹bshort@rockefeller.edu

The Journal of Cell Biology

|August 12, 2009

Summary

Systems biology integrates high-throughput omics data, such as genomics and proteomics, to analyze complex cellular interactions. Collaboration between systems and cell biologists is crucial for interpreting these large datasets and advancing biological understanding.

Area of Science:

Molecular biology
Systems biology
Bioinformatics

Background:

High-throughput omics technologies generate vast datasets on cellular components like proteins, transcripts, lipids, and metabolites.
Systems biology integrates these omics data to study complex interaction networks, moving beyond traditional single-protein or linear pathway analyses.
Cell biologists have expressed skepticism regarding the utility of raw omics data and interaction networks for answering fundamental biological questions.

Purpose of the Study:

To bridge the gap between systems biologists and cell biologists.
To highlight the mutual benefits of integrating omics data analysis with cell biology expertise.
To promote hypothesis-driven applications of omics technologies.

Main Methods:

More Related Videos

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

Published on: October 19, 2021

High-Quality Brain and Bone Marrow Nuclei Preparation for Single Nuclei Multiome Assays

High-Quality Brain and Bone Marrow Nuclei Preparation for Single Nuclei Multiome Assays

Published on: December 22, 2023

Related Experiment Videos

Last Updated: Jun 21, 2026

BioMEMS: Forging New Collaborations Between Biologists and Engineers

BioMEMS: Forging New Collaborations Between Biologists and Engineers

Published on: November 1, 2007

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

Published on: October 19, 2021

High-Quality Brain and Bone Marrow Nuclei Preparation for Single Nuclei Multiome Assays

High-Quality Brain and Bone Marrow Nuclei Preparation for Single Nuclei Multiome Assays

Published on: December 22, 2023

Integration and analysis of multi-omics datasets (proteomics, transcriptomics, metabolomics, lipidomics).

Computational analysis of complex biological networks.

Collaborative interpretation of data through interdisciplinary approaches.

Main Results:

Omics techniques are evolving from data acquisition to hypothesis-driven research.
The integration of omics data and computational analysis enhances the understanding of biological processes.
A narrowing gap exists between systems biology and cell biology perspectives.

Conclusions:

Cell biologists require omics data and computational analyses to deepen their understanding of cellular mechanisms.
Omics scientists need cell biologists' expertise to interpret and effectively utilize large-scale datasets.
Interdisciplinary collaboration is essential for maximizing the impact of omics research in biology.