Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors

Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors

Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...

Disorders of the Male Reproductive System

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...

Male Sexual Response: Erection & Ejaculation

Male Sexual Response: Erection & Ejaculation

Sexual stimulation can take various forms, such as physical touch and visual or auditory cues. When this happens, the parasympathetic reflex in the sacral portion of the spinal cord is activated. This reflex stimulates the release of nitric oxide (NO), which then dilates the arterioles in the penis, increasing blood flow to the erectile tissues - the corpora cavernosa and corpus spongiosum.
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...

Heart Failure V: Medical Management

Heart Failure V: Medical Management

Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...

Infertility in Males

Infertility in Males

Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Initial linguistic and cultural validation of the satisfaction survey for inflatable penile implant (SSIPI) in Spanish.

Actas urologicas espanolas·2025

Same author

Sildenafil Protects Endothelial Cells From Radiation-Induced Oxidative Stress.

The journal of sexual medicine·2019

Same author

Impact of cardiovascular risk factors and related comorbid conditions and medical therapy reported at baseline on the treatment response to tadalafil 5 mg once-daily in men with lower urinary tract symptoms associated with benign prostatic hyperplasia: an integrated analysis of four randomised, double-blind, placebo-controlled, clinical trials.

International journal of clinical practice·2015

Same author

Erectile function recovery in patients after non-nerve sparing radical prostatectomy.

Andrology·2014

Same author

Vasectomy reversal in the age of intracytoplasmic sperm injection.

Current opinion in urology·2006

Same author

Viagra: what's all the fuss about?

Current opinion in urology·2006

Search research articles

Related Experiment Video

Updated: Jun 21, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

Future directions in erectile dysfunction therapy.

¹Department of Urology, Loyola University Medical Center, Maywood, IL 60153, USA.

Postgraduate Medicine

|August 12, 2009

Summary

Research in sexual health has advanced the understanding of erectile impairment, leading to new therapies. This review covers current and emerging treatments for erectile dysfunction.

Area of Science:

Sexual Health
Urology
Andrology

Background:

Decades of research have improved understanding of erectile dysfunction (ED) physiology and pathophysiology.
This has driven the development of novel therapeutic agents and management strategies for ED.
The field anticipates continued emergence of new treatments.

Purpose of the Study:

To provide a framework for evaluating emerging ED therapies.
To review currently available therapeutic alternatives for erectile dysfunction.
To outline upcoming therapies on the horizon for ED management.

Main Methods:

Literature review of existing and emerging erectile dysfunction treatments.
Analysis of current therapeutic options based on physiological and pathophysiological understanding.

Related Experiment Videos

Last Updated: Jun 21, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

Synthesis of information on future treatment modalities.

Main Results:

Established therapies for erectile dysfunction are well-documented.
Several novel agents and management strategies are under development.
Future treatments aim to offer improved efficacy and safety profiles.

Conclusions:

A comprehensive understanding of ED pathophysiology underpins therapeutic advancements.
The current landscape offers multiple treatment options for erectile dysfunction.
Ongoing research promises further innovation in ED management.