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Related Concept Videos

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-IV: Nursing Management01:30

Asthma-IV: Nursing Management

The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
First, in...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

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Related Experiment Video

Updated: Jun 21, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Treating asthma in the new millennium.

J Corren1

  • 1University of California, Los Angeles, UCLA School of Medicine, USA. joncorren@hotmail.com

Postgraduate Medicine
|August 12, 2009
PubMed
Summary

New asthma treatments target specific molecular pathways, including IgE, interleukin-5, and adhesion molecules. These targeted therapies aim to reduce inflammation and improve patient compliance through potentially less frequent dosing.

Area of Science:

  • Pulmonology
  • Immunology
  • Pharmacology

Background:

  • Asthma pathophysiology involves airway inflammation driven by resident cells, leukocytes, mediators, and cytokines.
  • Understanding these cellular and molecular contributors has revealed new therapeutic targets.

Purpose of the Study:

  • To review emerging molecular targets and novel therapeutic strategies for moderate to severe asthma.
  • To highlight the potential benefits of targeted therapies in terms of efficacy and patient compliance.

Main Methods:

  • Review of current clinical development for novel asthma therapeutics.
  • Identification of key molecular targets including IgE, interleukins, cytokine/chemokine receptors, phosphodiesterase 4, and adhesion molecules.

Main Results:

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Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

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Last Updated: Jun 21, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
07:28

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

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  • Several new therapeutic classes are in development: antibodies to IgE and interleukin-5, interleukin-4 soluble receptors, cytokine/chemokine receptor antagonists, phosphodiesterase type 4 inhibitors, and adhesion molecule inhibitors.
  • Targeted approaches may minimize adverse effects.
  • Longer-acting agents could allow for weekly to monthly dosing.

Conclusions:

  • Advances in understanding asthma pathophysiology have led to the development of targeted molecular therapies.
  • These novel agents hold promise for improved treatment of moderate to severe asthma.
  • Potential for reduced side effects and enhanced patient compliance with new dosing schedules.