Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Translational development and first-in-human compassionate infusion of NK-92 cells expressing a CD5-based chimeric antigen receptor (SRCD5CAR-NK-92) in a patient with multidrug-resistant fusariosis.

Frontiers in immunology·2026
Same author

Exploring donor-derived cell-free DNA as a rejection biomarker during uterus transplant follow up.

Communications medicine·2026
Same author

Discovery of Donor-Derived Exosomal DNA as an Exploratory Biomarker of Kidney Graft Rejection: A Cross-Sectional Study.

Transplant international : official journal of the European Society for Organ Transplantation·2026
Same author

Chimeric Antigen Receptor T-Cell Therapy: More Than an Anti-Cancer Drug.

HLA·2026
Same author

Dual targeting of B cell compartments using belatacept and daratumumab in highly sensitized kidney transplant candidates: A mechanistic proof-of-concept desensitization trial.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same author

HLA and T-Cell Receptor Investigations in Idiopathic and Paraneoplastic Opsoclonus-Myoclonus in Children.

Neurology(R) neuroimmunology & neuroinflammation·2026

Related Experiment Video

Updated: Jun 21, 2026

Isolation and Transplantation of Different Aged Murine Thymic Grafts.
05:47

Isolation and Transplantation of Different Aged Murine Thymic Grafts.

Published on: May 13, 2015

Immunological senescence and thymic function in transplantation.

Ricardo Pujol-Borrell1, Maria Jose Herrero-Mata, Eduard Palou

  • 1Laboratory of Immunobiology for Research and Application to Diagnosis (LIRAD), Banc de Sang i Teixits (Blood and Tissue Bank), Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Badalona, Barcelona, Catalonia, Spain. rpujolb@servet.uab.es

Transplantation
|August 12, 2009
PubMed
Summary

Thymic function, crucial for immune tolerance, can be restored in adults, offering new avenues for organ transplantation. Research shows re-enacting thymic activity benefits patients and can be achieved through novel therapies.

More Related Videos

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
11:49

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Related Experiment Videos

Last Updated: Jun 21, 2026

Isolation and Transplantation of Different Aged Murine Thymic Grafts.
05:47

Isolation and Transplantation of Different Aged Murine Thymic Grafts.

Published on: May 13, 2015

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
11:49

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Area of Science:

  • Immunology
  • Transplantation Biology
  • Molecular Medicine

Background:

  • Thymic function was historically overlooked in organ transplantation.
  • Bone marrow transplant studies revealed adult thymopoiesis can persist and be reinduced.
  • The thymus plays a central role in establishing immune tolerance.

Purpose of the Study:

  • To explore the significance of thymic function in transplantation.
  • To investigate new tools for monitoring thymic activity.
  • To assess the potential of manipulating central tolerance for graft acceptance.

Main Methods:

  • Utilizing novel tools like T-cell receptor excision circles (TRECs) to monitor thymic function.
  • Employing markers for recently emigrated lymphocytes.
  • Applying new imaging techniques for thymic assessment.

Main Results:

  • Re-enactment of thymic activity is beneficial in bone marrow transplantation and HIV therapy.
  • Thymic activity can be successfully reinduced in adults.
  • Discovery of AIRE gene's role in expressing self-antigens within the thymus.

Conclusions:

  • Restoring thymic function offers therapeutic benefits in transplantation and disease.
  • The thymus's role in central tolerance presents opportunities for manipulating immune responses.
  • Translational research applying thymic biology principles to transplantation is advancing.