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Dideoxycytidine toxicity on mouse hemopoietic progenitors
M Mencoboni1, R Lerza, G Bogliolo
1Istituto Scientifico di Medicina Interna, Università di Genova, Italy.
In Vivo (Athens, Greece)
|May 1, 1990
Abstract:
Several antiviral compounds showed a toxicity or hemopoietic progenitor cells, 2', 3' Dideoxycytidine (ddc) is the most potent drug in vitro against human T cell lymphotropic viruses and is now being tested on patients with AIDS and AIDS-related complex. We studied its toxicity on mouse hemopoietic progenitors. Results reported here show a toxic activity of ddc but further studies are required to ascertain whether this toxicity is of significance during clinical application.