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Related Concept Videos

Angina III: Clinical Manifestations and Assessment01:29

Angina III: Clinical Manifestations and Assessment

Angina manifests as chest pain, tightness, or squeezing discomfort typically located behind the breastbone. It can radiate to the neck, jaw, shoulders, and inner aspects of the upper arms, most commonly the left arm. Patients may experience shortness of breath, fatigue, profuse sweating, dizziness, indigestion, heartburn, palpitations, anxiety, and vomiting as accompanying symptoms. This pain often lasts a few minutes and is triggered by physical exertion, emotional stress, heavy meals, or cold...
Angina I: Introduction01:30

Angina I: Introduction

Definition and Symptoms: Angina (angina pectoris) is chest pain or discomfort caused by myocardial ischemia, which occurs when the heart muscle receives insufficient oxygen-rich blood. It typically manifests as pressing, squeezing, or crushing sensations in the chest and may radiate to the shoulders, arms, neck, jaw, or back.Primary Cause: In a healthy state, the coronary arteries can dilate (widen) to increase blood flow and meet the increased oxygen demand during physical activity or...
Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Flail Chest-I01:24

Flail Chest-I

Overview of Flail Chest
Flail chest is a severe and potentially life-threatening condition characterized by the fracture of three or more adjacent ribs in multiple places. It is most commonly caused by direct impacts and trauma, such as motor vehicle accidents or injuries from a steering wheel impact. It can also occur due to falls in elderly individuals with osteoporosis, or assaults involving sharp objects.
Pathophysiology
The pathophysiology of flail chest is complex, involving fractures of...
Angina II: Classification01:27

Angina II: Classification

Angina, also known as angina pectoris, is a chest pain resulting from diminished blood flow to the heart muscle and is often a symptom of coronary artery disease. Angina presents several variants with distinctive attributes, etiologies, and therapeutic approaches. The main types of angina include stable, unstable, variant (Prinzmetal's), microvascular, intractable, and silent ischemia.Stable angina is caused by atherosclerosis, which leads to the formation of plaques that narrow the coronary...
The Thoracic Cage: Sternum01:17

The Thoracic Cage: Sternum

The thoracic or rib cage forms the body's thorax (chest) portion. Its primary function in the body is to protect vital organs in the thoracic cavity, such as the heart and the lungs. It consists of 12 pairs of ribs with their costal cartilages and the sternum. The ribs are anchored posteriorly to the 12 thoracic vertebrae (T1-T12).
The sternum is the elongated bony structure on the anterior side of the thoracic cage. It consists of three parts: the manubrium, the body, and the xiphoid process.

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Updated: Jun 21, 2026

Osteopathic Manipulative Treatment as a Useful Adjunctive Tool for Pneumonia
13:27

Osteopathic Manipulative Treatment as a Useful Adjunctive Tool for Pneumonia

Published on: May 6, 2014

A bone to pick about chest pain.

Kanishka Chakraborty1, Bharat Jenigiri, Agnes K Hamati

  • 1Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37601, USA. kanchakra@gmail.com

Southern Medical Journal
|August 12, 2009
PubMed
Summary
This summary is machine-generated.

Multiple myeloma can cause atypical chest pain, highlighting the need for broad differential diagnoses. Technetium-99m sestamibi imaging may aid in diagnosing this rare presentation.

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Practical Considerations for the Design, Execution, and Interpretation of Studies Involving Whole-Bone Bending Tests of Rodent Bones
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Practical Considerations for the Design, Execution, and Interpretation of Studies Involving Whole-Bone Bending Tests of Rodent Bones

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Last Updated: Jun 21, 2026

Osteopathic Manipulative Treatment as a Useful Adjunctive Tool for Pneumonia
13:27

Osteopathic Manipulative Treatment as a Useful Adjunctive Tool for Pneumonia

Published on: May 6, 2014

Practical Considerations for the Design, Execution, and Interpretation of Studies Involving Whole-Bone Bending Tests of Rodent Bones
04:20

Practical Considerations for the Design, Execution, and Interpretation of Studies Involving Whole-Bone Bending Tests of Rodent Bones

Published on: September 1, 2023

Area of Science:

  • Oncology
  • Radiology
  • Internal Medicine

Background:

  • Chest pain is a frequent symptom, often attributed to cardiac conditions.
  • Atypical chest pain necessitates a comprehensive differential diagnosis.
  • Multiple myeloma is a plasma cell malignancy with diverse clinical manifestations.

Observation:

  • A patient presented with atypical chest pain.
  • The chest pain was ultimately diagnosed as a symptom of multiple myeloma.
  • Standard cardiac evaluations did not reveal a cardiac origin for the pain.

Findings:

  • This case highlights an unusual presentation of multiple myeloma.
  • Multiple myeloma can manifest as atypical chest pain.
  • Technetium-99m sestamibi imaging demonstrated potential utility in diagnosing this condition.

Implications:

  • Emphasizes the importance of considering non-cardiac causes for atypical chest pain.
  • Suggests Tc-99m sestamibi imaging as a potential diagnostic tool for multiple myeloma.
  • Broadens the understanding of multiple myeloma's clinical spectrum.