Related Experiment Video
Updated: Jun 21, 2026
A Preterm Rat Model for Pain Studies
Published on: February 9, 2024
Sex differences in the relationship between maternal negative life events and children's laboratory pain responsivity
Subhadra Evans1, Jennie C I Tsao, Qian Lu
1Department of Pediatrics, Pediatric Pain Program, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. suevans@mednet.ucla.edu
Objectives:
Previous research has demonstrated links between psychosocial factors, including negative life events (NLE) and pain in children. This study examined sex differences in the relationship among mother-reported NLE, child NLE, mother somatization, and children's laboratory pain responses for heat, cold, and pressure pain tasks. We predicted that maternal NLE would be moderately associated with girls' pain responses but would not be associated with boys' pain responses.
Method:
Participants were 176 nonclinical children (89 boys) aged 8 to 18 years (mean = 12.2, SD = 2.7) and their mothers. Mothers and children completed questionnaires assessing their perceptions of NLE experienced in the previous 12 months.
Results:
Contrary to predictions, maternal NLE were related to pain responses in both boys and girls, although in opposite directions. Thus, increased maternal stress was associated with increased pain responses in girls but with decreased pain responses in boys. In addition, the impact of maternal NLE was only apparent for heat and pain tasks, indicating differential effects for various types of pain.
Conclusion:
The current findings underscore the importance of family variables in understanding sex differences in children's pain. Future research is needed to examine the mechanisms within the parent-child relationship that contribute to sex-differentiated pain outcomes, particularly under conditions of exacerbated parental stress.
