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Attaching Biological Probes to Silica Optical Biosensors Using Silane Coupling Agents
Published on: May 1, 2012
Bragg grating based biochemical sensor using submicron Si/SiO2 waveguides for lab-on-a-chip applications: a novel
Saurabh Mani Tripathi1, Arun Kumar, Emmanuel Marin
1Department of Physics, Indian Institute of Technology, New Delhi, 110016 Delhi, India. tripathi.iit@gmail.com
Applied Optics
|August 12, 2009
Summary
This study introduces a novel silica waveguide biochemical sensor. It offers high sensitivity for refractive index sensing, comparable to surface plasmon polariton sensors but without metallic layers, enabling lab-on-a-chip applications.
Area of Science:
- Photonics and optical sensing
- Biochemical sensing technologies
- Integrated optics
Background:
- Submicrometer waveguides are crucial for miniaturized optical devices.
- High refractive index contrast is key for enhanced sensor sensitivity.
- Existing biosensors often rely on metallic layers or bulky components.
Purpose of the Study:
- To propose and analyze a novel silica core Si-SiO(2) waveguide biochemical sensor.
- To optimize waveguide parameters for maximum sensitivity.
- To explore the sensor's performance for various refractive index samples.
Main Methods:
- Design and analysis of a submicrometer silica core Si-SiO(2) waveguide.
- Incorporation of a Bragg grating in the cladding region.
- Optimization of waveguide parameters for TE and TM modes.
- Sensitivity analysis for different ambient refractive indices.
Main Results:
- An optimum core width was identified for lower refractive index samples.
- TM mode configuration demonstrated significantly higher sensitivity (200-740 nm/RIU) for indices 1.33-1.63.
- The sensor achieved sensitivity comparable to surface plasmon polariton (SPP) based sensors.
- The proposed structure avoids metallic layers and bulky prisms, simplifying realization.
Conclusions:
- The novel waveguide sensor offers high sensitivity and is easily fabricated.
- Its simple structure and small dimensions facilitate integration with planar lightwave circuits.
- The device is suitable for lab-on-a-chip applications and advanced biochemical sensing.

