Use of viscoelastic substance in ophthalmic surgery - focus on sodium hyaluronate
Tomomi Higashide1, Kazuhisa Sugiyama
1Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
Abstract:
Among viscoelastic substances, sodium hyaluronate has become the most popular for intraocular surgeries since the introduction of Healon((R)) (sodium hyaluronate 1%, 4 x 10(6) daltons) in 1979. This review focuses on the recent development of a new generation of sodium hyaluronate agents with new rheologic properties and the relevant new techniques used in cataract, glaucoma, corneal, and vitreoretinal surgeries. The introduction of sodium hyaluronate agents with different rheologic properties has improved the safety and reliability of intraocular surgeries. Although there have been numerous studies reporting the effectiveness of viscoelastic substances in intraocular surgeries, rigorous validation by multi-center randomized control trials is lacking in many cases. At present, no single viscoelastic agent is most suitable to all of the various intraocular surgical techniques. Therefore, ophthalmologic surgeons should keep up with recent developments of viscoelastic agents and relevant surgical techniques for better patient care.
Related Concept Videos
Ophthalmic Drug Delivery Systems
Substance Use Disorders Affecting Sleep
Understanding the concepts of physical dependence,...
Deleterious Substances in Aggregate
Another type of impurity is clay and fine material that...
Regulation of Sodium and Potassium
Sodium Regulation
Sodium ions make up approximately 90% of extracellular cations, with a normal blood plasma concentration of 136–148 mEq/L. A decrease in blood volume and pressure triggers the release of renin from granular cells in the juxtaglomerular complex (JGC), primarily...
Connective Tissue Fibers and Ground Substance
Roles of Electrolytes: Sodium and Potassium


