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In the aftermath of the Fusarium keratitis outbreak: What have we learned?
1North Shore Contact Lens and Vision Consultants, PC, One Expressway, Plaza – Suite 100, Roslyn Heights, NY 11577, USA. artepstein@artepstein.com
Abstract:
The 2005-2006 outbreak of Fusarium keratitis associated with soft hydrophilic contact lens wear was both unprecedented and unexpected. More than 250 cases have been reported worldwide that have primarily been associated with Bausch & Lomb ReNu with MoistureLoc and, more recently, with Bausch and Lomb ReNu MultiPlus multipurpose contact lens disinfecting solutions. This article documents the outbreak, presenting the time line and the historical and scientific basis for its occurrence. Underlying causes are explored including likely mechanisms of contamination and subsequent corneal infection. Thorough exploration of this unique occurrence affords the opportunity to examine contact lens and lens care actions and interactions and to develop greater understanding of possible associated risks and ways to minimize them.
Insights
The 2005-2006 Fusarium keratitis outbreak linked to soft contact lenses, particularly ReNu solutions, affected over 250 worldwide. This study examines the outbreak
Area of Science:
- Ophthalmology
- Infectious Diseases
- Microbiology
Background:
- An unprecedented outbreak of Fusarium keratitis occurred globally between 2005-2006.
- This outbreak was strongly associated with soft hydrophilic contact lens wear.
- Specifically, Bausch & Lomb ReNu with MoistureLoc and ReNu MultiPlus solutions were implicated in over 250 reported cases.
Purpose of the Study:
- To document the timeline and scientific basis of the 2005-2006 Fusarium keratitis outbreak.
- To explore the underlying causes, including contamination and infection mechanisms.
- To analyze contact lens and care product interactions to understand associated risks and mitigation strategies.
Main Methods:
- Review and documentation of the outbreak's timeline.
- Scientific investigation into the historical basis of the occurrence.
- Exploration of contamination and corneal infection pathways.
Main Results:
- Over 250 cases of Fusarium keratitis reported worldwide.
- Strong association identified between the outbreak and specific multipurpose contact lens solutions.
- Identification of potential contamination and infection mechanisms.
Conclusions:
- The outbreak highlighted significant risks associated with specific contact lens care products.
- Understanding the outbreak provides insights into preventing future contact lens-related infections.
- Further research is needed to minimize risks and ensure contact lens wear safety.
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