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Updated: Jun 21, 2026
06:15
Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Topical treatment options for conjunctival neoplasms
Jonathan W Kim1, David H Abramson
1Ophthalmic Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Clinical Ophthalmology (Auckland, N.Z.)
|August 12, 2009
Summary
Topical therapies provide a nonsurgical option for conjunctival tumors, delivering high drug concentrations to the eye. This review offers guidelines for treating melanocytic and squamous neoplasms, evaluating current data and clinical experience.
Area of Science:
- Ophthalmology
- Oncology
Background:
- Topical therapies offer a nonsurgical approach for conjunctival tumors, achieving high drug concentrations on the ocular surface.
- These agents have been investigated for premalignant and malignant conjunctival lesions including primary acquired melanosis with atypia, conjunctival melanoma, and squamous cell carcinoma over the past decade.
Purpose of the Study:
- To review the clinical efficacy of topical agents for conjunctival neoplasms.
- To provide treatment guidelines for melanocytic and squamous conjunctival neoplasms based on literature and clinical experience.
Main Methods:
- Literature review of topical therapies for conjunctival tumors.
- Analysis of clinical experience at Memorial Sloan-Kettering Cancer Center.
Main Results:
- Topical agents are increasingly used for conjunctival tumors, but questions remain about cure rates compared to traditional therapies.
- Long-term effects of prolonged topical chemotherapy on the ocular surface are unknown, and optimal regimens are still being refined.
Conclusions:
- Topical therapies represent a promising nonsurgical treatment for conjunctival neoplasms.
- Further research is needed to establish optimal regimens and long-term safety profiles.
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