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Prognostic impact of C-REL expression in diffuse large B-cell lymphoma
Choladda V Curry1, April A Ewton, Randall J Olsen
1Pathology, The Methodist Hospital Research Institute, The Methodist Hospital, 6565 Fannin St MS-205, Houston, TX, 77030, USA.
Journal of Hematopathology
|August 12, 2009
Summary
Germinal center B-cell (GCB) Diffuse Large B-cell Lymphoma (DLBCL) generally has a better prognosis. However, c-REL nuclear expression in GCB DLBCL may negatively impact overall survival, suggesting a refined prognostic role.
Area of Science:
- Hematology
- Oncology
- Molecular Pathology
Background:
- Diffuse Large B-cell Lymphoma (DLBCL) subtypes, germinal center B-cell (GCB) and activated B-cell (ABC), exhibit distinct prognoses.
- Previous research implicates nuclear factor-kappaB (NF-kappaB) in ABC DLBCL and c-REL amplification in GCB DLBCL.
Purpose of the Study:
- To investigate the prognostic significance of c-REL nuclear expression in de novo DLBCL.
- To evaluate the correlation between c-REL expression, GCB/non-GCB phenotype, and overall survival (OS).
Main Methods:
- Immunohistochemical analysis of c-REL, BCL-6, CD10, and MUM1/IRF4 in 68 DLBCL cases.
- Kaplan-Meier survival (KMS) analysis to assess overall survival (OS) based on phenotype and c-REL expression.
Main Results:
- GCB phenotype was associated with better OS compared to non-GCB phenotype (p = 0.016).
- c-REL nuclear expression was observed in 65% of cases but generally did not correlate with phenotype or OS.
- GCB DLBCL with negative c-REL nuclear expression showed significantly better OS than GCB DLBCL with positive c-REL (p = 0.045).
Conclusions:
- c-REL nuclear expression may serve as an independent prognostic factor in DLBCL.
- Combining c-REL expression with GCB/non-GCB phenotyping could enhance patient risk stratification for DLBCL.
