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Related Concept Videos

Diffusion01:21

Diffusion

Diffusion is a type of passive transport. In passive transport, a substance tends to move from an area of high concentration to an area of low concentration until the concentration is equal across the space. For example, take the diffusion of substances through the air. When someone opens a perfume bottle in a room filled with people, the perfume is at its highest concentration in the bottle and is at its lowest at the edges of the room. The perfume vapor will diffuse, or spread away, from the...
Diffusion01:12

Diffusion

Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
Behavior of Gas Molecules: Molecular Diffusion, Mean Free Path, and Effusion03:48

Behavior of Gas Molecules: Molecular Diffusion, Mean Free Path, and Effusion

Although gaseous molecules travel at tremendous speeds (hundreds of meters per second), they collide with other gaseous molecules and travel in many different directions before reaching the desired target. At room temperature, a gaseous molecule will experience billions of collisions per second. The mean free path is the average distance a molecule travels between collisions. The mean free path increases with decreasing pressure; in general, the mean free path for a gaseous molecule will be...
Protein Diffusion in the Membrane01:24

Protein Diffusion in the Membrane

Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...
Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model01:09

Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model

Various dissolution theories provide insight into the factors that influence the dissolution rate. Danckwerts' Model suggests that turbulence, rather than a stagnant layer, characterizes the dissolution medium at the solid-liquid interface. In this model, the agitated solvent contains macroscopic packets that move to the interface via eddy currents, facilitating the absorption and delivery of the drug to the bulk solution. The regular replenishment of solvent packets maintains the concentration...
Passive Diffusion: Overview and Kinetics01:17

Passive Diffusion: Overview and Kinetics

Passive diffusion is a critical process that allows small lipophilic drugs to cross the cell membrane along a concentration gradient. This mechanism's efficiency depends on four primary factors: the membrane's surface area, the drug's lipid-water partition coefficient, the concentration gradient, and the membrane's thickness.
When administered orally, drugs establish a substantial concentration gradient between the gastrointestinal (GI) lumen and the bloodstream, expediting their diffusion into...

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Related Experiment Video

Updated: Jun 21, 2026

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level
06:55

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level

Published on: September 26, 2016

Superdiffusion in a model for diffusion in a molecularly crowded environment.

Dietrich Stauffer1, Christian Schulze, Dieter W Heermann

  • 1Institut für Theoretische Physik, Universität zu Köln, 50923 Köln, Germany. stauffer@thp.uni-koeln.de

Journal of Biological Physics
|August 12, 2009
PubMed
Summary
This summary is machine-generated.

Molecular crowding creates complex diffusion patterns. Our model shows that random barriers lead to normal diffusion long-term but anomalous sub- and superdiffusion at intermediate times.

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Spot Variation Fluorescence Correlation Spectroscopy for Analysis of Molecular Diffusion at the Plasma Membrane of Living Cells

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Area of Science:

  • Physics
  • Physical Chemistry

Background:

  • Diffusion is fundamental to molecular transport.
  • Molecular crowding significantly impacts diffusion dynamics.
  • Understanding anomalous diffusion is crucial for biological and chemical processes.

Purpose of the Study:

  • To model diffusion in molecularly crowded environments.
  • To investigate the effects of random barriers on diffusion.
  • To characterize anomalous diffusion behaviors.

Main Methods:

  • Developed a model incorporating random barriers within a percolation network.
  • Simulated random walks in the presence of slowly moving barriers.
  • Analyzed the relationship between squared distance and time.

Main Results:

  • Observed normal diffusion at long times.
  • Identified anomalous diffusion (sub- and superdiffusion) at intermediate times.
  • Found that effective diffusion exponents can be <1 or >1 depending on barrier concentration.

Conclusions:

  • Molecular crowding leads to complex diffusion phenomena.
  • The proposed model captures both normal and anomalous diffusion regimes.
  • Sub- and superdiffusion are characteristic of crowded environments with random barriers.