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Updated: Jun 21, 2026

Analyzing and Building Nucleic Acid Structures with 3DNA
Published on: April 26, 2013
Nonlinearity in DNA and its relation to specific functions
Boian Alexandrov1, Kim Ø Rasmussen, Alan R Bishop
1Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA. boian@lanl.gov
Abstract:
In memory of Alwyn Scott, we discuss the connection between the nonlinear dynamics of double-stranded DNA, experimental findings, and specific DNA functions. We begin by discussing how thermally induced localized openings (bubbles) of the DNA double-strand are important for interpreting dynamic force spectroscopy data. Then, we demonstrate a correlation between the sequence-dependent propensity for bubble formation and transcription initiation and other regulatory effects in viral DNA. Finally, we discuss the possibility of a connection between DNA dynamics and the ability of repair proteins to recognize ultraviolet-radiation damage.
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