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Related Concept Videos

DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
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The DNA Helix01:07

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Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...
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Human DNA is almost two meters long. However, it is compressed inside a tiny nucleus measuring only a few microns in diameter. To make this degree of compaction possible, DNA is organized into several sequential levels so that it can fit into such a tiny space. The most compact form of DNA is a chromosome that can be seen under a microscope in a dividing cell.
In a chromosome, DNA is wound twice around a protein complex called a histone octamer core, which consists of 8 histone proteins. This...

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Analyzing and Building Nucleic Acid Structures with 3DNA
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Nonlinearity in DNA and its relation to specific functions.

Boian Alexandrov1, Kim Ø Rasmussen, Alan R Bishop

  • 1Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA. boian@lanl.gov

Journal of Biological Physics
|August 12, 2009
PubMed
Summary
This summary is machine-generated.

DNA dynamics, specifically bubble formation, are linked to gene regulation and DNA repair. Understanding these nonlinear dynamics aids in interpreting experimental data and DNA functions.

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Area of Science:

  • Biophysics
  • Molecular Biology
  • Genetics

Background:

  • Nonlinear dynamics of double-stranded DNA are crucial for biological functions.
  • Thermally induced DNA double-strand openings (bubbles) are key to interpreting dynamic force spectroscopy data.

Purpose of the Study:

  • To explore the connection between DNA nonlinear dynamics, experimental findings, and DNA functions.
  • To correlate DNA bubble formation propensity with regulatory effects and DNA repair.

Main Methods:

  • Analysis of thermally induced DNA double-strand openings (bubbles).
  • Correlation of sequence-dependent bubble formation propensity with viral DNA transcription initiation and regulatory effects.
  • Discussion of DNA dynamics in relation to ultraviolet-radiation damage recognition by repair proteins.

Main Results:

  • DNA bubble formation is important for interpreting dynamic force spectroscopy data.
  • A correlation exists between sequence-dependent bubble formation propensity and transcription initiation/regulation in viral DNA.

Conclusions:

  • DNA nonlinear dynamics, particularly bubble formation, are intrinsically linked to essential DNA functions like gene regulation.
  • Further investigation into DNA dynamics may illuminate mechanisms of DNA repair, such as recognition of ultraviolet-radiation damage.