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Published on: June 8, 2021
Using oral ziprasidone effectively: the food effect and dose-response
1Department of Psychiatry, Nathan S. Kline Institute for Psychiatric Research, New York University School of Medicine, Orangeburg, NY 10962, USA. citrome@nki.rfmh.org
Advances in Therapy
|August 12, 2009
Summary
Ziprasidone is an atypical antipsychotic effective for schizophrenia and bipolar disorder. Optimal results require specific dosing and administration with a meal, offering metabolic benefits over other treatments.
Area of Science:
- Pharmacology
- Psychiatry
Background:
- Ziprasidone is a second-generation antipsychotic approved for schizophrenia and bipolar disorder.
- Meta-analyses show comparable efficacy to quetiapine/aripiprazole, but less than olanzapine/risperidone for schizophrenia.
Purpose of the Study:
- To evaluate the efficacy and tolerability of ziprasidone.
- To identify optimal dosing and administration strategies for ziprasidone.
Main Methods:
- Review of meta-analyses comparing ziprasidone with other second-generation antipsychotics.
- Analysis of factors influencing ziprasidone efficacy, including dose titration and meal administration.
Main Results:
- Optimal symptom control and treatment persistence with ziprasidone (120-160 mg/day) requires administration with a 500 kcal meal.
- Ziprasidone offers advantages in tolerability, with no significant weight gain or adverse metabolic effects.
- Low incidence of anticholinergic, extrapyramidal, or prolactin-related side effects; somnolence is a potential side effect.
Conclusions:
- Ziprasidone can be an effective treatment for schizophrenia and bipolar disorder when prescribed at adequate doses and taken with a meal.
- Its favorable metabolic profile and tolerability make it a valuable option, avoiding common long-term antipsychotic side effects.
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