[Changes in the electric activity of the cerebral cortex in poisoning caused by Cl. perfringens toxin type A]

The electrical activity of the cerebral cortex was recorded in cats under mild nembutal anesthesia (15-20 mg/kg of body weight) during the development of Cl. perfringens, type A, toxin poisoning (the toxin was injected intramuscularly in a dose of 100 MLD per kg of body weight). Two phases of the changes in the electrical activity of the cerebral cortex were noted. The first phase was attended by the desynchronization of the electrical activity, persistence of the induced potentials and of the reaction of the rhythm reconstruction to the rhythmic light stimulus. No desynchronization occurred under conditions of preliminary section of the midbrain (on the mesencephalic preparation), this indicating the involvement of the reticular formation into the pathological process and pointing to its role in the desynchronization effect. A profound depression of the electrical activity of the brain, depression of induced potentials and disturbance of the reaction of the rhythm reconstruction occurred during the second phase.