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Published on: December 4, 2007
[Effect of intravenous laser blood irradiation on endothelial dysfunction in patients with hypertensive disease]
Insights
Intravenous laser blood irradiation (ILBI) improved endothelial function in hypertensive patients. This therapy normalized nitric oxide (NO) levels and reduced Willebrand factor activity, aiding blood pressure management.
Area of Science:
- Cardiovascular Medicine
- Medical Laser Applications
Background:
- Hypertensive disease (HD) is linked to endothelial dysfunction, characterized by altered nitric oxide (NO) production and elevated Willebrand factor.
- NO plays a crucial role in vascular homeostasis, and its reduced synthesis is associated with increased arterial pressure (AP).
Purpose of the Study:
- To investigate the efficacy of intravenous laser blood irradiation (ILBI) as an adjunct therapy for endothelial dysfunction in patients with hypertensive disease.
- To assess the impact of ILBI on NO metabolites and Willebrand factor activity in hypertensive patients.
Main Methods:
- A study involving 120 patients with grade I-II hypertensive disease, divided into a control group (traditional therapy) and a study group (traditional therapy plus ILBI).
- Endothelial function was assessed by measuring plasma concentrations of stable NOx metabolites (nitrates, nitrites) and Willebrand factor.
- ILBI was administered using a Mulat laser therapy device.
Main Results:
- Hypertensive patients exhibited elevated Willebrand factor activity and varied responses in the NO generating system.
- A negative correlation was observed between NO production and both systolic (r = -0.59) and diastolic (r = -0.64) arterial pressure.
- ILBI treatment led to a significant reduction in Willebrand factor activity and normalization of NO levels.
Conclusions:
- ILBI is an effective therapeutic approach for improving endothelial dysfunction in hypertensive patients.
- The normalization of NO levels and reduction in Willebrand factor activity by ILBI contribute to better vascular health in hypertension management.
Abstract:
The aim of this work was to study effect of intravenous laser blood irradiation (ILBI) on endothelial dysfunction in 120 patients (mean age 53.4 +/- 1.3 yr) with grade I-II hypertensive disease (HD) allocated to 2 groups. Traditional drug therapy given to patients of control group was supplemented by ILBI using a Mulat laser therapy device in the study group. Endothelial function was evaluated from the total plasma concentration of stable NOx metabolites, nitrates (NO3-), nitrites (NO2-), and Willebrand's factor. HD patients were found to have elevated activity of the Willebrand factor and show 3 types of response of the NO generating system: (1) decreased NO synthesis, (2) lack of its changes, and (3) increased NO synthesis. NO production in HD patients negatively correlated with systolic (r = -0.59) and diastolic (r = - 0.64) arterial pressure (AP) which suggests the relationship between decreased NO production and elevated AP. Inclusion of ILBl in the therapy of HD resulted in a significant decrease of Willebrand's factor activity and normalization of the NO level regardless of its initial value.
