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Updated: Jun 21, 2026

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
Published on: February 10, 2015
[Effect pf cholecystectomy on bile lithogenecity and morphological changes in the pancreas of patients with chronic
Abstract:
The authors consider mechanism of biliary dysfunction in cholelithiasis responsible for the development of secondary changes in parenchyma and pancreatic ductal system and effect of cholecystectomy on bile lithogenecity in patients with chronic biliary pancreatitis. A high-precision technique for instrumental diagnosis (endosonography) yielded data on the role of microliths and biliary sludge in pathogenesis of chronic biliary pancreatitis. The necessity to use ursodeoxycholic acid derivatives for the treatment of this pathology is substantiated.
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