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Total synthesis of irciniastatin A (Psymberin)
Michael T Crimmins1, Jason M Stevens, Gregory M Schaaf
1Kenan and Caudill Laboratories of Chemistry, University of North Carolina at Chapel Hill, North Carolina 27599, USA. crimmins@email.unc.edu
Organic Letters
|August 13, 2009
Abstract:
The total synthesis of (+)-iriciniastatin A (psymberin) is reported in 19 steps and 6% overall yield. Key reactions include a highly convergent enolsilane-oxocarbenium ion union to generate the C8-C25 fragment and a late-stage coupling of a hemiaminal and acid chloride to complete the synthesis.
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