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Updated: Jun 21, 2026

Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-1
07:59

Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-1

Published on: December 5, 2020

Antiangiogenic drugs in ovarian cancer

Maurie Markman1

  • 1The University of Texas MD Anderson Cancer Center, Department of Gynecologic Medical Oncology, Houston, Texas 77005, USA. mmarkman@mdanderson.org

Expert Opinion on Pharmacotherapy
|August 13, 2009
PubMed
Abstract

Insights

New antiangiogenic agents show promise for treating advanced epithelial ovarian cancer. Further Phase III trials are expected to confirm their role in altering standard treatment approaches for this malignancy.

Area of Science:

  • Oncology
  • Cancer Research
  • Medical Therapeutics

Background:

  • Advanced epithelial ovarian cancer requires novel treatment strategies.
  • Tumor angiogenesis is a key process in ovarian cancer progression.
  • Current management approaches for advanced ovarian cancer have limitations.

Purpose of the Study:

  • To review the rationale for targeting tumor angiogenesis in ovarian cancer.
  • To present initial clinical findings of antiangiogenic therapies.
  • To establish angiogenesis inhibition as a novel treatment paradigm.

Main Methods:

  • Review of preclinical data supporting antiangiogenic therapy.
  • Analysis of Phase II clinical trial outcomes for antiangiogenic agents.
  • Discussion of ongoing Phase III clinical trials.

Main Results:

  • Phase II trials indicate significant therapeutic potential for antiangiogenic agents.
  • Initial results suggest these agents can impact advanced ovarian cancer.
  • The data support further investigation in larger trials.

Conclusions:

  • Antiangiogenic agents demonstrate potential as a major therapeutic option for advanced ovarian cancer.
  • Ongoing Phase III trials are crucial for validating this strategy.
  • Results from Phase III trials may lead to changes in standard ovarian cancer management.

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