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Updated: Jun 21, 2026

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
Published on: November 29, 2024
[Clinical observation of heparin-induced thrombocytopenia]
Hong-yan Tian1, Yan Meng, Jun-bo Zhang
1Department of Cardiology and Peripheral Vascular Diseases, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, 710061, China. tianhhyy@mail.xjtu.edu.cn
Objective:
To explore the treatment of heparin-induced thrombocytopenia (HIT) in venous thromboembolism.
Methods:
A total of 202 patients with venous thromboembolism without anticoagulation contraindications were enrolled. All of them were treated with low molecular weight heparin (LMWH) and/or unfractionated heparin (UFH). The peripheral blood cells were examined regularly.
Results:
HIT occurred in 6 patients. And argatroban was used to treat HIT. The overall incidence rate of HIT in this study was 2.97%. The time of occurrence of HIT was about Days 3 - 9 after using heparin. The platelet recovered to the basic level at Days 3 - 7 after withdrawing heparin and initiating argatroban.
Conclusion:
The count of platelet should be measured in the patients receiving regular LMWH and/or UFH therapy. And the above regimen should be discontinued timely when the platelet count declined progressively by over 50%. Argatroban was effective.
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