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Updated: Jun 21, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
[Cardiovascular events in patients with chronic kidney disease]
Lei Meng1, Wen-hui Ding, Li-bin Shi
1Department of Cardiology, Peking University First Hospital, Beijing 100034, China.
Insights
Anemia is a significant risk factor for cardiovascular events in chronic kidney disease (CKD) patients. Identifying and managing these risk factors, including anemia, can reduce mortality in CKD patients.
Area of Science:
- Nephrology
- Cardiology
- Internal Medicine
Context:
- Cardiovascular events are a leading cause of mortality in patients with chronic kidney disease (CKD).
- Understanding risk factors is crucial for improving outcomes in CKD patients.
- This study focuses on patients with stages III-V CKD.
Purpose:
- To identify and analyze the risk factors associated with cardiovascular events in CKD patients.
- To investigate the impact of these risk factors on mortality.
- To highlight the role of anemia as a modifiable risk factor.
Summary:
- A retrospective analysis of 557 CKD patients (stage III-V) identified key risk factors for cardiovascular events.
- Independent risk factors included advanced age, prior coronary heart disease, anemia, and elevated fasting blood glucose.
- Patients experiencing cardiovascular events had a significantly higher mortality rate (29.3%) compared to those without (9.82%).
Impact:
- Anemia is identified as an independent risk factor for cardiovascular events in CKD, beyond traditional factors.
- The findings underscore the importance of managing anemia to mitigate cardiovascular risk in CKD.
- Reducing cardiovascular events in CKD patients can significantly lower overall mortality.
Objective:
Cardiovascular event is common and is an important cause of death for patients with chronic kidney disease (CKD). The purpose of current study is to analyze the related risk factors of cardiovascular event in patients with CKD.
Methods:
Clinical data from 557 patients with CKD (stage III-V) who hospitalized in our hospital from Jan 2006 to Dec 2006 were retrospectively analyzed focusing on the risk factors of cardiovascular event and their impacts on death.
Results:
Among the 557 patients with CKD, 332 were male and 225 were female. There were totally 163 patients (163/557, 29.3%) suffered from cardiovascular events during hospitalization. The independent risk factors for cardiovascular event were age, history of coronary heart disease, anemia and fasting blood glucose level. The mortality was significantly higher in patients suffered from cardiovascular events than that in patients without cardiovascular events (9.82% vs. 2.28%, P<0.001).
Conclusions:
For patients with CKD, anemia is another independent risk factor for cardiovascular events besides traditional risk factors and the mortality was significantly higher in CKD patients with cardiovascular events compared to CKD patients without cardiovascular events.
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