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Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

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Related Experiment Video

Updated: Jun 21, 2026

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
11:12

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

Autoimmunity in common variable immunodeficiency.

Shradha Agarwal1, Charlotte Cunningham-Rundles

  • 1Mount Sinai Medical Center, New York, NY 10029, USA.

Current Allergy and Asthma Reports
|August 13, 2009
PubMed
Summary
This summary is machine-generated.

Common variable immunodeficiency (CVID) involves immune system dysregulation, leading to infections and autoimmunity. This review explores CVID-associated autoimmune conditions, their mechanisms, and treatment strategies.

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Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
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Published on: November 1, 2015

Area of Science:

  • Immunology
  • Clinical Medicine

Background:

  • Common variable immunodeficiency (CVID) is a primary immune defect characterized by hypogammaglobulinemia.
  • CVID involves immune system dysregulation, impacting T-cell activation, dendritic cells, and cytokine production.
  • Recurrent sinopulmonary infections are common, affecting 70-80% of patients, alongside frequent autoimmune and inflammatory complications.

Purpose of the Study:

  • To review autoimmune conditions associated with CVID.
  • To explore potential mechanisms of immune dysregulation in CVID.
  • To discuss therapeutic strategies for managing autoimmunity in CVID patients.

Main Methods:

  • Literature review of autoimmune conditions in CVID.
  • Analysis of immune dysregulation mechanisms.
  • Summary of current and emerging treatment options.

Main Results:

  • Autoimmunity is a frequent complication of CVID, with immune thrombocytopenic purpura and hemolytic anemia being most common.
  • Other autoimmune conditions include rheumatoid arthritis, pernicious anemia, thyroiditis, and inflammatory bowel disease.
  • Effective treatment involves immunoglobulins, corticosteroids, and other immune modulators.

Conclusions:

  • Autoimmune manifestations are a significant aspect of CVID, requiring comprehensive management.
  • Understanding immune dysregulation is key to developing targeted therapies.
  • Multifaceted treatment approaches are necessary for CVID-associated autoimmunity.