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Asthma I: Introduction

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

Asthma-I: Introduction

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

Allergic Reactions

Allergic Reactions

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...

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Related Experiment Video

Updated: Jun 21, 2026

Flow Cytometric Analysis of Particle-bound Bet v 1 Allergen in PM10

Flow Cytometric Analysis of Particle-bound Bet v 1 Allergen in PM10

Published on: November 19, 2016

Allergens and thunderstorm asthma.

Shuaib M Nasser¹, Thomas B Pulimood

¹Department of Allergy, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, United Kingdom. shuaib.nasser@addenbrookes.nhs.uk

Current Allergy and Asthma Reports

|August 13, 2009

Summary

This summary is machine-generated.

Thunderstorm asthma epidemics are linked to fungal spores like Alternaria. A combination of sensitized individuals, prior airway hyperresponsiveness, and specific thunderstorm conditions triggers these events.

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Murine Model of Allergen Induced Asthma

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Last Updated: Jun 21, 2026

Flow Cytometric Analysis of Particle-bound Bet v 1 Allergen in PM10

Flow Cytometric Analysis of Particle-bound Bet v 1 Allergen in PM10

Published on: November 19, 2016

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

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Published on: June 4, 2017

Murine Model of Allergen Induced Asthma

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Area of Science:

Environmental Health
Allergology
Meteorology

Background:

Thunderstorm-asthma is a recognized global health concern.
Fungal spores, particularly Alternaria, are implicated in asthma exacerbations during thunderstorms.

Purpose of the Study:

To review advances in understanding the mechanisms of thunderstorm-related asthma.
To elucidate the role of fungal allergens in asthma epidemics linked to thunderstorms.

Main Methods:

Literature review focusing on allergen mechanisms and thunderstorm impacts.
Analysis of observational data on asthma epidemics and environmental factors.

Main Results:

Identified four key prerequisites for thunderstorm-asthma.
Highlighted the role of sudden, large-scale exposure to respirable allergenic fragments, especially Alternaria spores.

Conclusions:

Thunderstorm-asthma requires a sensitized asthmatic individual with pre-existing airway hyperresponsiveness.
Specific meteorological conditions during allergen seasons are critical for triggering widespread asthma events.