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Related Experiment Video

Updated: Jun 21, 2026

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

[Hepatitis E transmission in Denmark].

Jens Lindberg¹, Blenda Böttiger, Heléne Norder

¹Medicinsk Afdeling, Regionshospitalet Herning, DK-7400 Hernning. jens.lindberg@mail.dk

Ugeskrift for Laeger

|August 13, 2009

Summary

Hepatitis E virus genotype 3 can cause acute hepatitis, even without travel history. Phylogenetic analysis linked a patient's infection to a swine strain, highlighting pigs as potential reservoirs for this zoonotic virus.

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Area of Science:

Hepatology
Virology
Genomic Epidemiology

Background:

Hepatitis E virus (HEV) genotype 3 is an emerging cause of acute hepatitis in developed countries.
Zoonotic transmission from animals, particularly swine, is a recognized route of HEV infection.
The typical clinical presentation often involves exposure history, such as travel or animal contact.

Observation:

A case of acute hepatitis was diagnosed in a patient with no recent travel history or known animal contact.
Serological and genomic sequencing confirmed the presence of hepatitis E virus genotype 3.
Phylogenetic analysis revealed the viral strain was identical to one previously isolated from a Swedish pig.

Findings:

The study identified a human case of acute hepatitis E genotype 3 infection.
Genomic sequencing and phylogenetic analysis established a direct link between the patient's HEV strain and a swine-derived strain.
This finding supports the role of swine as a reservoir for HEV genotype 3, facilitating zoonotic transmission.

Implications:

Healthcare professionals should consider acute hepatitis E in patients presenting with hepatitis of unknown origin, irrespective of travel history.
Swine farming and consumption of pork products may represent significant exposure pathways for HEV genotype 3 in non-endemic regions.
Enhanced surveillance and public health awareness are crucial for managing and preventing HEV genotype 3 infections in the general population.