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Toxicological Assays for Testing Effects of an Epigenetic Drug on Development, Fecundity and Survivorship of Malaria Mosquitoes
Published on: January 16, 2015
A little bit of sugar makes polycomb better
Yuri B Schwartz1, Vincenzo Pirrotta
1Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA. schwartz@biology.rutgers.edu
Abstract:
Transcriptional repression by Polycomb group (PcG) proteins is now sweetened by the discovery of the essential role of O-GlcNAc glycosylation in the process. PcG protein polyhomeotic may be the key target, but alternative or additional functions including repression of transcription through glycosylation of the C-terminal domain of RNA polymerase II are also possible.
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