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MDM2 controls the timely expression of cyclin A to regulate the cell cycle

Rebecca Frum1, Mahesh Ramamoorthy, Lathika Mohanraj

  • 1Department of Biochemistry and Molecular Biology, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298, USA.

Molecular Cancer Research : MCR
|August 13, 2009
PubMed
Summary

MDM2 (mouse double minute 2 homolog) controls cell cycle progression by regulating cyclin A expression. Cancer cells lacking p53, p16, or BRG1 can evade this MDM2-mediated growth arrest.

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