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Updated: Jun 21, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

Immunogenetic studies on systemic lupus erythematosus.

G D Sebastiani¹, M Galeazzi

¹Unità Operativa Complessa di Reumatologia, Azienda Ospedaliera San Camillo-Forlanini, Roma, Italy. gsebastiani@scamilloforlanini.rm.it

|August 13, 2009

Summary

Genetic studies are crucial for understanding systemic lupus erythematosus (SLE) pathogenesis. Analyzing genetic variants helps identify fundamental mechanisms predisposing individuals to this complex autoimmune disease.

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Area of Science:

Immunogenetics
Autoimmune Diseases
Systemic Lupus Erythematosus (SLE)

Background:

The pathogenesis of SLE is complex, involving abnormalities in both innate and adaptive immunity.
Immunological dysfunction in SLE often precedes clinical symptoms by many years.
SLE has a strong genetic basis, making genetic studies vital for understanding its mechanisms.

Purpose of the Study:

To review SLE immunogenetic studies conducted in collaboration with the European Working Party on Systemic Lupus Erythematosus.
To understand how dysregulation in key immunological steps predisposes to SLE development.
To leverage genetic analysis for identifying fundamental, causative disease mechanisms.

Main Methods:

Review of previously conducted SLE immunogenetic studies.

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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

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Last Updated: Jun 21, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Integration of findings with recent advances from genome-wide association studies (GWAS).

Analysis of susceptibility variants present from birth, unaffected by disease course or treatment.

Main Results:

Genetic analysis offers a unique approach to identifying fundamental SLE disease mechanisms.
Dysregulation at specific immunological steps is linked to SLE predisposition.
Collaborative research and GWAS have advanced the understanding of SLE immunogenetics.

Conclusions:

Genetic studies are essential for unraveling the complex pathogenesis of SLE.
Identifying genetic susceptibility variants provides insights into the root causes of SLE.
Understanding immunogenetic underpinnings can lead to better insights into SLE development.