The OMERACT MRI inflammatory arthritis group: advances and future research priorities

Philip G Conaghan1, Paul Bird, Fiona McQueen

  • 1Section of Musculoskeletal Disease, Chapel Allerton Hospital, Leeds, UK. p.conaghan@leeds.ac.uk

Insights

The OMERACT group refined MRI scoring for rheumatoid arthritis (RAMRIS) and developed a preliminary psoriatic arthritis MRI score (PsAMRIS) for inflammatory arthritis research. Future work will focus on feasibility, imaging remission, and enhancing PsAMRIS.

Area of Science:

  • Rheumatology and Medical Imaging
  • Development of standardized outcome measures for inflammatory arthritis

Background:

  • The Outcome Measures in Rheumatology (OMERACT) magnetic resonance imaging (MRI) group has a history of developing and evaluating MRI scoring systems for inflammatory arthritis.
  • Previous work includes the Rheumatoid Arthritis MRI Score (RAMRIS) and initiation of the Psoriatic Arthritis MRI Score (PsAMRIS).

Framework:

  • OMERACT 9 focused on clarifying RAMRIS application and assessing gadolinium contrast agent effects on RAMRIS outcomes.
  • Significant effort was dedicated to the iterative development and validation of the PsAMRIS.

Implementation:

  • Exercises examining the preliminary PsAMRIS demonstrated encouraging results.
  • Data presented at OMERACT 9 led to the subsequent presentation of a preliminary PsAMRIS.

Implications:

  • Discussions highlighted key research priorities including feasibility studies for MRI in psoriatic arthritis.
  • Future research directions include understanding imaging remission and further refining the PsAMRIS for clinical utility.

Related Concept Videos

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...