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The OMERACT MRI inflammatory arthritis group: advances and future research priorities
Philip G Conaghan1, Paul Bird, Fiona McQueen
1Section of Musculoskeletal Disease, Chapel Allerton Hospital, Leeds, UK. p.conaghan@leeds.ac.uk
Abstract:
The OMERACT magnetic resonance imaging (MRI) in inflammatory arthritis group previously developed the rheumatoid arthritis MRI score (RAMRIS) for use in clinical studies, evaluated the use of extremity MRI, and initiated development of a psoriatic arthritis MRI score (PsAMRIS). At OMERACT 9 the group looked at clarifications of applying the RAMRIS, and presented data from a study examining how the contrast agent gadolinium affects RAMRIS outcomes. Much of the group's effort has been aimed at the iterative development of its PsA score, and reported exercises examining this score demonstrated encouraging results, allowing subsequent presentation of a preliminary PsAMRIS. The large amount of data presented were followed by discussions with the wider audience highlighting constructive suggestions for future research priorities, including further feasibility studies, understanding imaging remission, and further improvements to PsAMRIS.
Insights
The OMERACT group refined MRI scoring for rheumatoid arthritis (RAMRIS) and developed a preliminary psoriatic arthritis MRI score (PsAMRIS) for inflammatory arthritis research. Future work will focus on feasibility, imaging remission, and enhancing PsAMRIS.
Area of Science:
- Rheumatology and Medical Imaging
- Development of standardized outcome measures for inflammatory arthritis
Background:
- The Outcome Measures in Rheumatology (OMERACT) magnetic resonance imaging (MRI) group has a history of developing and evaluating MRI scoring systems for inflammatory arthritis.
- Previous work includes the Rheumatoid Arthritis MRI Score (RAMRIS) and initiation of the Psoriatic Arthritis MRI Score (PsAMRIS).
Framework:
- OMERACT 9 focused on clarifying RAMRIS application and assessing gadolinium contrast agent effects on RAMRIS outcomes.
- Significant effort was dedicated to the iterative development and validation of the PsAMRIS.
Implementation:
- Exercises examining the preliminary PsAMRIS demonstrated encouraging results.
- Data presented at OMERACT 9 led to the subsequent presentation of a preliminary PsAMRIS.
Implications:
- Discussions highlighted key research priorities including feasibility studies for MRI in psoriatic arthritis.
- Future research directions include understanding imaging remission and further refining the PsAMRIS for clinical utility.
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