Relationships of soluble E-selectin and high-sensitivity C-reactive protein with carotid atherosclerosis in Japanese

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Updated: Jun 21, 2026

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
09:33

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

Published on: February 7, 2015

Susumu Sakurai1, Akihiko Kitamura, Renzhe Cui

  • 1Department of Public Health, Doctoral Program in Social Medicine, Graduate School of Medicine, Ehime University, Ehime, Japan.

Journal of Atherosclerosis and Thrombosis
|August 13, 2009
PubMed

Insights

Soluble E-selectin (sE-selectin) and high-sensitivity C-reactive protein (hs-CRP) are associated with carotid atherosclerosis. Higher levels of these biomarkers correlate with increased carotid intima-media thickness and plaque prevalence in Japanese men.

Area of Science:

  • Cardiovascular Medicine
  • Biomarkers
  • Atherosclerosis Research

Background:

  • E-selectin and C-reactive protein are implicated in carotid atherosclerosis.
  • Previous findings on their association with carotid atherosclerosis have been inconsistent.

Purpose of the Study:

  • To investigate the association of soluble E-selectin (sE-selectin) and high-sensitivity C-reactive protein (hs-CRP) with carotid intima-media thickness (IMT).
  • To evaluate the relationship between these biomarkers and the prevalence of heterogeneous plaque in Japanese men.

Main Methods:

  • Cross-sectional study involving 505 Japanese men aged 60-74 years.
  • Measurement of serum sE-selectin and hs-CRP levels.
  • Assessment of maximum carotid intima-media thickness (IMT) in common (CCA) and internal carotid arteries (ICA).
  • Statistical analysis adjusted for age, cardiovascular risk factors, and other biomarkers.

Main Results:

  • sE-selectin levels were positively associated with maximum CCA and ICA IMT.
  • hs-CRP levels showed a trend towards positive association with maximum CCA IMT.
  • Higher tertiles of both sE-selectin and hs-CRP were associated with a higher prevalence of heterogeneous plaque.

Conclusions:

  • Serum levels of sE-selectin and hs-CRP may serve as potential biomarkers for atherosclerosis.
  • These findings suggest their utility in assessing atherosclerosis risk in the general population.
Abstract

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