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Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice
Published on: February 14, 2021
Baroreflex sensitivity is impaired in patients with obstructive jaundice
Jian-Gang Song1, Yun-Fei Cao, Yu-Ming Sun
1Department of Anesthesiology, Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Anesthesiology
|August 13, 2009
Summary
Obstructive jaundice impairs baroreflex sensitivity, affecting both sympathetic and vagal functions. This impairment may increase perioperative risks in jaundiced patients, potentially linked to elevated atrial natriuretic peptide levels.
Area of Science:
- Cardiovascular Physiology
- Gastroenterology
- Surgical Complications
Background:
- Obstructive jaundice increases perioperative risks, including shock and renal failure.
- Normal arterial baroreflex function is crucial for hemodynamic stability and sepsis survival.
Purpose of the Study:
- To investigate if baroreflex sensitivity is diminished in patients with obstructive jaundice.
- To explore potential mechanisms underlying baroreflex impairment in jaundice.
Main Methods:
- Evaluated baroreflex sensitivity using a modified Oxford pharmacologic technique in 35 jaundiced and 30 control patients.
- Measured liver biochemistry and plasma levels of methionine-enkephalin, atrial natriuretic peptide, and nitrate.
Main Results:
- Jaundiced patients exhibited significantly reduced sympathetic and vagal baroreflex sensitivity compared to controls (P < 0.01).
- A significant inverse correlation was found between plasma atrial natriuretic peptide and sympathetic baroreflex sensitivity in jaundiced patients (r = -0.44, P = 0.008).
Conclusions:
- Baroreflex sensitivity is impaired in obstructive jaundice, potentially contributing to perioperative complications.
- Increased plasma atrial natriuretic peptide levels may be implicated in the observed baroreflex dysfunction.
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