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Symptomatic and asymptomatic rotavirus and norovirus infections during infancy in a Chilean birth cohort

Miguel L O'Ryan1, Yalda Lucero, Valeria Prado

  • 1Microbiology and Mycology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile. moryan@med.uchile.cl

The Pediatric Infectious Disease Journal
|August 13, 2009
PubMed

Insights

Rotavirus and norovirus are common causes of diarrhea in children. Rotavirus infections were generally more severe than norovirus, with norovirus reinfections being more frequent.

Area of Science:

  • Pediatric Infectious Diseases
  • Virology
  • Epidemiology

Background:

  • Rotavirus and norovirus are leading causes of acute diarrhea in children.
  • Comparative analyses in birth cohorts are crucial for understanding clinical and viral behaviors.

Purpose of the Study:

  • To compare rotavirus and norovirus infections in a Chilean birth cohort.
  • To analyze clinical presentation, viral shedding, and reinfection patterns.

Main Methods:

  • Longitudinal study of 198 mother-infant pairs over 18 months.
  • Monthly evaluation for asymptomatic viral excretion and during acute diarrhea episodes (ADE).
  • Severity assessed using the Vesikari score; bacterial pathogens also identified.

Main Results:

  • Rotavirus and norovirus detected in 15% and 18% of ADEs, respectively.
  • Rotavirus infections showed higher mean Vesikari scores (10.4) than norovirus (7.4).
  • Norovirus reinfections were more common (44% asymptomatic, 40% symptomatic) than rotavirus (19% asymptomatic, 11% symptomatic).

Conclusions:

  • Children experienced a mean of 1.4 ADEs by 18 months, with rotavirus and norovirus causing 15% and 18% respectively.
  • Rotavirus infections were generally more severe than norovirus infections, irrespective of age.
  • While norovirus reinfections were more frequent, primary GII norovirus infection appeared protective against clinically significant reinfections.
Abstract

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