Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Persistent immune complexes and abnormal CD4/CD8 ratios in HIV infection.

S Roy1, W J Morrow, C Christian

  • 1Department of Laboratory Medicine, University of California, San Francisco 94143.

Journal of Acquired Immune Deficiency Syndromes
|January 1, 1990
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Estimated US Trends in SARS-CoV-2 Spike Antibody Concentrations and Correlation to Risk of First-Time Infections Based on Blood Donations, 2022.

The Journal of infectious diseases·2025
Same author

The effect of an intervention to promote isoniazid preventive therapy on leadership and management abilities.

Public health action·2024
Same author

Estimated dates of detectable infection (EDDIs) as an improvement upon Fiebig staging for HIV infection dating.

Epidemiology and infection·2020
Same author

Detection of Zika virus RNA in semen of asymptomatic blood donors.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2017
Same author

Moving towards a reliable HIV incidence test - current status, resources available, future directions and challenges ahead.

Epidemiology and infection·2016
Same author

Manufacturing method affects mitochondrial DNA release and extracellular vesicle composition in stored red blood cells.

Vox sanguinis·2016

Persistent immune complexes in human immunodeficiency virus (HIV) infection were common in gay/bisexual men but did not predict disease progression. This finding impacts understanding of HIV immunopathology.

Area of Science:

  • Immunology
  • Virology
  • Epidemiology

Background:

  • Circulating immune complexes (CICs) are implicated in various autoimmune and infectious diseases.
  • Their role in human immunodeficiency virus (HIV) infection pathogenesis and progression remains incompletely understood.
  • Understanding CICs in HIV may offer insights into disease management and immune responses.

Purpose of the Study:

  • To investigate the immunopathologic role of CICs in HIV infection.
  • To determine if CICs correlate with disease progression in a cohort of men.
  • To assess the prevalence of specific immunoglobulin types (IgM, IgG) in CICs within the HIV-positive population.

Main Methods:

  • Utilized serum samples from the San Francisco Men's Health Study, a longitudinal HIV/AIDS research cohort.

Related Experiment Videos

  • Tested 4,276 sera from 1,023 men for the presence of CICs using a modified enzyme immunoassay.
  • Employed monoclonal anti-C1q antibodies for CIC capture and anti-IgG/anti-IgM probes for detection.

    • Main Results:

    • Persistent IgM and IgG CICs were frequently detected in HIV-seropositive homosexual/bisexual men.
    • The presence of these CICs did not correlate with disease progression markers.
    • No significant association was found between CICs and abnormalities in CD4/CD8 T-cell counts or clinical AIDS/ARC indicators.

    Conclusions:

    • Persistent CICs are common in HIV-infected gay and bisexual men.
    • CICs are not reliable indicators of HIV disease progression or severity.
    • Further research is needed to elucidate the specific role, if any, of CICs in HIV pathogenesis.