Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Focal cerebral dysfunction in developmental learning disabilities.

H C Lou1, L Henriksen, P Bruhn

  • 1John F. Kennedy Institute, Glostrup, Denmark.

Lancet (London, England)
|January 6, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Addressing Domestic Violence in Antenatal Care Environments in Nepal (ADVANCE) - study protocol for a randomized controlled trial evaluating a video intervention on domestic violence among pregnant women.

BMC public health·2023
Same author

Factors associated with the level of physical activity in a multi-ethnic pregnant population - a cross-sectional study at the time of diagnosis with gestational diabetes.

BMC pregnancy and childbirth·2022
Same author

Coeliac disease in Caucasian and South Asian patients in the North West of England.

Journal of human nutrition and dietetics : the official journal of the British Dietetic Association·2019
Same author

'It is a difficult topic' - a qualitative study of midwives´ experiences with routine antenatal enquiry for intimate partner violence.

BMC pregnancy and childbirth·2017
Same author

Towards a cognitive neuroscience of self-awareness.

Neuroscience and biobehavioral reviews·2016
Same author

Thalamic infarcts: Effects on cerebral blood flow, metabolism, and neuropsychological function.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2015
Same journal

Medical compartmentalisation: a patient with chromosome 22q11.2 deletion syndrome in Japan.

Lancet (London, England)·2026
Same journal

[<sup>177</sup>Lu]Lu-edotreotide versus everolimus for gastroenteropancreatic neuroendocrine tumours (COMPETE): a phase 3, multicentre, randomised, open-label, superiority trial.

Lancet (London, England)·2026
Same journal

Research priorities for characterising Bundibugyo virus.

Lancet (London, England)·2026
Same journal

Rethinking treatment sequence in advanced gastroenteropancreatic neuroendocrine tumours.

Lancet (London, England)·2026
Same journal

Dual mobility total hip replacement in fractures: stability promotes patient confidence.

Lancet (London, England)·2026
Same journal

Dual mobility versus standard cups in total hip replacement for displaced femoral neck fractures (Duality): an international, multicentre, randomised, controlled, superiority trial.

Lancet (London, England)·2026
See all related articles

This study examined regional brain activity in children with learning disabilities. Attention deficit and hyperactivity disorder (ADHD) was linked to abnormal activity in specific brain regions.

Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Pediatric Neurology

Background:

  • Developmental learning disabilities affect numerous children.
  • Attention deficit and hyperactivity disorder (ADHD) and dysphasia are common learning disabilities.
  • Understanding the neurobiological underpinnings of these conditions is crucial.

Purpose of the Study:

  • To investigate regional cerebral activity patterns in children with developmental learning disabilities.
  • To identify differences in brain activity between children with ADHD, dysphasia, and combined conditions compared to controls.
  • To explore the relationship between specific learning disability subtypes and localized brain function.

Main Methods:

  • Utilized xenon-133 single photon emission tomography (SPECT) to assess regional cerebral blood flow.

Related Experiment Videos

  • Studied a cohort of 24 children diagnosed with developmental learning disabilities.
  • Included 15 age-matched typically developing children as controls.

    • Main Results:

    • Children with pure ADHD exhibited reduced activity in striatal and posterior periventricular regions, with increased activity in occipital areas.
    • Children with ADHD combined with phonologic-syntactic dysphasia showed similar reductions in striatal and posterior periventricular activity.
    • Children with dysphasia but without hyperactivity displayed decreased cerebral activity in left temporofrontal regions.

    Conclusions:

    • Specific patterns of regional cerebral activity are associated with different subtypes of developmental learning disabilities.
    • ADHD appears linked to dysfunction in striatal and periventricular brain areas.
    • Dysphasia is associated with altered activity in left temporofrontal brain regions.