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Updated: Jun 21, 2026
Human Vastus Lateralis Skeletal Muscle Biopsy Using the Weil-Blakesley Conchotome
Published on: March 4, 2016
Open muscle biopsy in suspected myopathy: diagnostic yield and clinical utility
1Department of Neurology, Changhua Christian Hospital, Changhua, Taiwan.
Background:
The purpose of the study was to investigate the diagnostic yield and clinical utility of open muscle biopsy and to identify pre-biopsy factors that might predict useful clinical results for suspected myopathy.
Methods:
Two-hundred fifty-eight muscle biopsies, performed for investigation of suspected myopathy, were evaluated.
Results:
A specific clinical diagnosis following muscle biopsy was made in 43% of cases. As a result of the biopsy, clinical diagnosis was changed in 47% and treatment was changed in 33% of cases. Results either led to a specific clinical diagnosis or changed the diagnosis/treatment in 74% of patients. Positive family history of myopathy and findings of myopathic irritability on electromyography had a negative predictive value for diagnosis change.
Conclusions:
Open muscle biopsy is useful in myopathy evaluation in the modern genetic era.
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