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Updated: Jun 21, 2026

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
Published on: August 16, 2018
Structure and potential function of gamma-aminobutyrate type A receptor-associated protein
Jeannine Mohrlüder1, Melanie Schwarten, Dieter Willbold
1Institut für Strukturbiologie und Biophysik (ISB-3), Forschungszentrum Jülich, Germany. j.mohrlueder@fz-juelich.de
Abstract:
The gamma-aminobutyrate type A receptor-associated protein (GABARAP) is a ubiquitin-like modifier, and is implicated in a variety of membrane trafficking and fusion events that are crucial to synaptic plasticity, autophagy and apoptosis. However, important aspects of GABARAP function and regulation remain poorly understood. We review the current state of knowledge about GABARAP, highlighting newly-identified GABARAP ligands, and discuss the possible physiological relevance of each ligand interaction.
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