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Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA
Published on: December 15, 2023
Community-based hepatitis B screening programs in the United States in 2008
D B Rein1, S B Lesesne, P J Leese
1RTI International, Atlanta, GA 30341, USA. drein@rti.org
Journal of Viral Hepatitis
|August 14, 2009
Summary
Community programs screen many foreign-born individuals for hepatitis B (HBV) infection, identifying high hepatitis B surface antigen (HBsAg) prevalence. However, current screening efforts may not fully meet CDC recommendations for HBV testing.
Area of Science:
- Public Health
- Infectious Disease Epidemiology
- Hepatitis B Virus (HBV) Research
Background:
- The Centers for Disease Control and Prevention (CDC) recommends hepatitis B surface antigen (HBsAg) testing for foreign-born individuals from high-prevalence areas (> or = 2%).
- Independent community organizations are primary providers of HBsAg screening in the United States.
- Understanding the scope and effectiveness of these community-based screening programs is crucial for public health strategies.
Purpose of the Study:
- To gather information on community-based HBsAg screening programs in the United States.
- To assess the reach, target populations, and effectiveness of these screening initiatives.
- To evaluate the contribution of community programs to meeting national HBV screening recommendations.
Main Methods:
- Identification of potential screening programs through known contacts, interviews, and internet searches.
- Data collection via email surveys and follow-up phone calls.
- Analysis of program location, number screened, services offered, target demographics, and HBsAg prevalence.
Main Results:
- 31 community HBsAg screening programs were contacted, screening an estimated 21,817 individuals in the past year.
- An average HBsAg prevalence of 8.1% was observed among those screened.
- Programs primarily targeted individuals from Asia, with limited screening of those from Africa, Eastern Europe, or US-born individuals at behavioral risk; geographic gaps in screening were noted.
Conclusions:
- Community HBsAg screening programs are effective in identifying individuals with HBV infection, as indicated by high prevalence rates.
- Current community-based efforts, while valuable, are likely insufficient to meet the CDC's recommended HBV screening needs.
- Targeted expansion and improved geographic distribution of screening programs are necessary to address the full scope of the HBV epidemic.
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