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Urinary uric acid : creatinine ratios in healthy Turkish children

Hakan M Poyrazoğlu1, Ruhan Düşünsel, Cevat Yazici

  • 1Department of Pediatric Nephrology, Erciyes University School of Medicine, Kayseri, Turkey. drpoyrazoglu@yahoo.com

Pediatrics International : Official Journal of the Japan Pediatric Society
|August 14, 2009
PubMed

Insights

Urinary uric acid to creatinine ratios in children vary significantly with age, establishing crucial regional reference values for Turkish children. These findings highlight the importance of age-specific interpretation for accurate uric acid excretion assessment.

Area of Science:

  • Pediatric Nephrology
  • Clinical Chemistry
  • Biochemical Markers

Background:

  • Assessing uric acid excretion in children is vital for understanding metabolic health.
  • Urinary uric acid to creatinine ratio (UACR) is a key indicator, but requires accurate reference values.
  • Geographic and age-related variations necessitate region-specific UACR data.

Purpose of the Study:

  • To establish regional reference values for urinary uric acid to creatinine ratios in healthy Turkish children.
  • To provide age-specific UACR data for accurate clinical interpretation.

Main Methods:

  • Analyzed 1306 healthy Turkish children aged 1 month to 15 years.
  • Determined urinary uric acid and creatinine levels from second non-fasting morning urine samples.
  • Utilized uricase method for uric acid and Jaffe reaction for creatinine analysis.

Main Results:

  • Established age-specific mean +/- SD and 5th-95th percentiles for UACR across various pediatric age groups.
  • Observed a significant decrease in UACR with increasing age in children.
  • Found no significant difference between genders except in the 12-15 year group, where girls had higher UACR.

Conclusions:

  • Urinary uric acid to creatinine ratio demonstrates a clear age-dependent pattern in children.
  • Clinicians must consider the child's age when interpreting UACR values for accurate uric acid excretion assessment.
Abstract

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