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Related Concept Videos

Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Diversity in Cell Signaling Responses01:22

Diversity in Cell Signaling Responses

The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity. 
Graded and Abrupt Responses
Some signaling systems generate...
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the addition of a...
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
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Updated: Jun 21, 2026

High-Throughput Behavioral Aging and Lifespan Assays Using the Lifespan Machine
08:53

High-Throughput Behavioral Aging and Lifespan Assays Using the Lifespan Machine

Published on: January 26, 2024

Converging pathways in lifespan regulation.

Sri Devi Narasimhan1, Kelvin Yen, Heidi A Tissenbaum

  • 1Program in Gene Function and Expression, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA.

Current Biology : CB
|August 14, 2009
PubMed
Summary
This summary is machine-generated.

Understanding organism lifespan involves complex processes. This review highlights how insulin/insulin-like growth factor 1 (IGF-1) signaling and dietary restriction, though seemingly independent, are intricately linked and respond to nutritional status to influence longevity.

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A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
10:39

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

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Last Updated: Jun 21, 2026

High-Throughput Behavioral Aging and Lifespan Assays Using the Lifespan Machine
08:53

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Published on: January 26, 2024

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
10:39

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

Area of Science:

  • Gerontology and Molecular Biology
  • Investigating the biological basis of aging and lifespan determination.

Background:

  • Organism lifespan determination is complex, with interventions delaying age-related decline.
  • Insulin/insulin-like growth factor 1 (IGF-1) signaling and dietary restriction are key modulators of longevity.

Purpose of the Study:

  • To review recent findings on IGF-1 signaling and the genetic basis of dietary restriction.
  • To explore the interconnectedness of IGF-1 signaling and dietary restriction pathways in lifespan regulation.

Main Methods:

  • Multi-species comparative analysis of conserved molecular components.
  • Review and synthesis of current research on IGF-1 signaling and dietary restriction pathways.

Main Results:

  • Insulin/IGF-1 signaling and dietary restriction pathways share conserved molecular components across species.
  • Numerous interactions exist between IGF-1 signaling and dietary restriction pathways at multiple levels.

Conclusions:

  • IGF-1 signaling and dietary restriction pathways are intricately connected, not independent.
  • Both pathways have evolved to sense nutritional status, impacting organism lifespan.