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The etiology of cervical artery dissection
Michael T Haneline1, Anthony L Rosner
1Professor, Palmer College of Chiropractic West, Department of Research, San Jose, CA 95134.
Insights
Cervical artery dissection (CAD) etiology remains unclear, with potential links to cervical spine manipulation in susceptible individuals. Further research is needed to identify specific risk factors and causal relationships.
Area of Science:
- Neurology
- Vascular Medicine
- Anatomy
Background:
- Cervical artery dissection (CAD) etiology is not fully understood.
- A number of risk factors have been associated with CAD.
- CAD can rarely occur after cervical spine manipulation.
Purpose of the Study:
- To review the anatomy of cervical arteries.
- To discuss the developmental features, epidemiology, and pathogenesis of CAD.
- To analyze potential risk factors and the relationship between cervical manipulation and CAD.
Main Methods:
- This commentary reviews existing literature on cervical artery anatomy, CAD development, epidemiology, and dissection mechanisms.
- It analyzes proposed risk factors for CAD.
- It discusses the potential role of cervical spine manipulation.
Main Results:
- The precise cause of CAD is unknown, despite identified risk factors.
- Many individuals exposed to potential triggers do not develop CAD.
- A definitive cause-and-effect link between cervical manipulation and CAD is not established.
Conclusions:
- Cervical spine manipulation may trigger CAD in susceptible patients or worsen existing dissections.
- The specific factors predisposing individuals to CAD after manipulation remain unidentified.
- Further investigation is required to clarify CAD etiology and risk factors.
Abstract:
The etiology of cervical artery dissection (CAD) is unclear, although a number of risk factors have been reported to be associated with the condition. On rare occasions, patients experience CAD after cervical spine manipulation, making knowledge about the cervical arteries, the predisposing factors, and the pathogenesis of the condition of interest to chiropractors. This commentary reports on the relevant anatomy of the cervical arteries, developmental features of CAD, epidemiology of the condition, and mechanisms of dissection. The analysis of CAD risk factors is confusing, however, because many people are exposed to mechanical events and known pathophysiological associations without ever experiencing dissection. No cause-and-effect relationship has been established between cervical spine manipulation and CAD, but it seems that cervical manipulation may be capable of triggering dissection in a susceptible patient or contributing to the evolution of an already existing CAD. Despite the many risk factors that have been proposed as possible causes of CAD, it is still unknown which of them actually predispose patients to CAD after cervical spine manipulation.
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