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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Oral Drug Delivery Systems: Delayed-Release Systems

Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...

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Related Experiment Video

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Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface
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Prolonged local antibiotics delivery from hydroxyapatite functionalised with cyclodextrin polymers.

Stéphane Leprêtre1, Feng Chai, Jean-Christophe Hornez

  • 1Laboratoire de Chimie Organique et Macromoléculaire UMR CNRS8009, Université Lille Nord de France, 59655 Villeneuve d'Ascq, France.

Biomaterials
|August 14, 2009
PubMed
Summary

This study developed a novel hydroxyapatite (HA) bone graft material functionalized with hydroxypropyl-beta-cyclodextrin polymer (polyHPbetaCD) for sustained antibiotic delivery, effectively reducing infection risk in bone surgery.

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Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
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Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Orthopedic Surgery

Background:

  • Per-operative infection is a significant risk in bone-graft surgery.
  • Current methods struggle with localized, sustained drug delivery at surgical sites.
  • Hydroxyapatite (HA) is a widely used bone substitute material.

Purpose of the Study:

  • To functionalize hydroxyapatite (HA) with hydroxypropyl-beta-cyclodextrin polymer (polyHPbetaCD) for sustained antibiotic delivery.
  • To evaluate the drug loading, release kinetics, and efficacy of the functionalized HA.
  • To assess the cytocompatibility of the modified material with osteoblasts.

Main Methods:

  • Incorporation of polyHPbetaCD into microporous HA via impregnation and thermal fixation.
  • Loading of ciprofloxacin (CFX) and vancomycin (VCM) onto functionalized HA (CD-HA).
  • Analysis using Infrared-spectroscopy and Thermogravimetric analysis; kinetic release tests; bacteriostatic activity assays; cell culture studies.

Main Results:

  • Successful incorporation of polyHPbetaCD into HA confirmed by spectroscopy.
  • CD-HA demonstrated significantly increased initial antibiotic burst and prolonged release compared to non-functionalized HA.
  • Antibiotic-loaded CD-HA showed prolonged bacteriostatic activity against Staphylococcus aureus and enhanced osteoblast cytocompatibility.

Conclusions:

  • PolyHPbetaCD functionalization of HA provides an effective platform for sustained local antibiotic delivery.
  • This approach holds promise for preventing surgical site infections in orthopedic procedures.
  • The developed CD-HA material offers a dual benefit of bone regeneration support and infection prophylaxis.