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Exon Recombination02:32

Exon Recombination

The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
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Related Experiment Video

Updated: Jun 21, 2026

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
09:34

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

Published on: October 25, 2018

Characterization & evolutionary analysis of human CD36 gene.

Gauri Awasthi1, Aditya P Dash, Aparup Das

  • 1Evolutionary Genomics & Bioinformatics Laboratory, National Institute of Malaria Research (ICMR) New Delhi, India.

The Indian Journal of Medical Research
|August 14, 2009
PubMed
Summary
This summary is machine-generated.

This study analyzed the human CD36 gene

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Last Updated: Jun 21, 2026

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
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qKAT: Quantitative Semi-automated Typing of Killer-cell Immunoglobulin-like Receptor Genes
07:58

qKAT: Quantitative Semi-automated Typing of Killer-cell Immunoglobulin-like Receptor Genes

Published on: March 6, 2019

Area of Science:

  • Evolutionary genetics
  • Comparative genomics
  • Immunoinformatics

Background:

  • Understanding immune system genes is crucial for infectious disease pathogenesis.
  • Malaria poses a significant global health challenge, necessitating research into host-pathogen interactions.
  • The CD36 gene plays a role in malaria pathogenesis, making its evolutionary analysis important.

Purpose of the Study:

  • To characterize the evolutionary and comparative details of the human CD36 gene.
  • To investigate the evolutionary relationships of CD36 across different taxa.
  • To provide insights into genetic diversity relevant to malaria.

Main Methods:

  • Retrieved and analyzed human CD36 gene DNA sequences.
  • Performed comparative and evolutionary analyses with CD36 homologs from seven taxa.
  • Utilized statistical analyses and constructed a Neighbor-joining tree.

Main Results:

  • Detected differential exon/intron distribution and uneven CpG island distribution in CD36 across taxa.
  • Revealed recent evolutionary divergence of CD36 between humans and chimpanzees.
  • Observed significant divergence of chicken CD36 and copy number variations across species.

Conclusions:

  • Comparative genomics of CD36 illuminates evolutionary relationships among taxa.
  • Findings can aid in studying genetic diversity in malaria-endemic regions.
  • This research contributes to understanding malaria pathogenesis through an evolutionary lens.